ID   M3ZCP1_HUMAN            Unreviewed;       735 AA.
AC   M3ZCP1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Receptor-type tyrosine-protein phosphatase C {ECO:0000313|Ensembl:ENSP00000356337};
DE   Flags: Fragment;
GN   Name=PTPRC {ECO:0000313|Ensembl:ENSP00000356337};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356337, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000356337, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000356337}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00160}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL157402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL355988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M3ZCP1; -.
DR   jPOST; M3ZCP1; -.
DR   MaxQB; M3ZCP1; -.
DR   PeptideAtlas; M3ZCP1; -.
DR   PRIDE; M3ZCP1; -.
DR   Ensembl; ENST00000367367; ENSP00000356337; ENSG00000081237.
DR   UCSC; uc010ppg.3; human.
DR   EuPathDB; HostDB:ENSG00000081237.18; -.
DR   HGNC; HGNC:9666; PTPRC.
DR   OpenTargets; ENSG00000081237; -.
DR   eggNOG; KOG4228; Eukaryota.
DR   eggNOG; COG5599; LUCA.
DR   GeneTree; ENSGT00940000159457; -.
DR   ChiTaRS; PTPRC; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000081237; Expressed in 219 organ(s), highest expression level in blood.
DR   ExpressionAtlas; M3ZCP1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IEA:InterPro.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR024739; PTP_recept_N.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016335; Ptprc.
DR   Pfam; PF12567; CD45; 1.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF12453; PTP_N; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00194; PTPc; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00897767, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:M3ZCP1,
KW   ECO:0000213|MaxQB:M3ZCP1, ECO:0000213|PeptideAtlas:M3ZCP1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    735       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004046277.
FT   TRANSMEM    512    533       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      325    417       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      418    510       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      587    735       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   NON_TER     735    735       {ECO:0000313|Ensembl:ENSP00000356337}.
SQ   SEQUENCE   735 AA;  82982 MW;  AAD088B0DC1CB527 CRC64;
     MTMYLWLKLL AFGFAFLDTE VFVTGQSPTP SPTGVSSVQT PHLPTHADSQ TPSAGTDTQT
     FSGSAANAKL NPTPGSNAIS DVPGERSTAS TFPTDPVSPL TTTLSLAHHS SAALPARTSN
     TTITANTSDA YLNASETTTL SPSGSAVIST TTIATTPSKP TCDEKYANIT VDYLYNKETK
     LFTAKLNVNE NVECGNNTCT NNEVHNLTEC KNASVSISHN SCTAPDKTLI LDVPPGVEKF
     QLHDCTQVEK ADTTICLKWK NIETFTCDTQ NITYRFQCGN MIFDNKEIKL ENLEPEHEYK
     CDSEILYNNH KFTNASKIIK TDFGSPGEPQ IIFCRSEAAH QGVITWNPPQ RSFHNFTLCY
     IKETEKDCLN LDKNLIKYDL QNLKPYTKYV LSLHAYIIAK VQRNGSAAMC HFTTKSAPPS
     QVWNMTVSMT SDNSMHVKCR PPRDRNGPHE RYHLEVEAGN TLVRNESHKN CDFRVKDLQY
     STDYTFKAYF HNGDYPGEPF ILHHSTSYNS KALIAFLAFL IIVTSIALLV VLYKIYDLHK
     KRSCNLDEQQ ELVERDDEKQ LMNVEPIHAD ILLETYKRKI ADEGRLFLAE FQSIPRVFSK
     FPIKEARKPF NQNKNRYVDI LPYDYNRVEL SEINGDAGSN YINASYIDGF KEPRKYIAAQ
     GPRDETVDDF WRMIWEQKAT VIVMVTRCEE GNRNKCAEYW PSMEEGTRAF GDVVVKINQH
     KRCPDYIIQK LNIVN
//