ID M0R3C9_HUMAN Unreviewed; 1286 AA. AC M0R3C9; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 16-JAN-2019, entry version 43. DE SubName: Full=Neurogenic locus notch homolog protein 3 {ECO:0000313|Ensembl:ENSP00000473138}; DE Flags: Fragment; GN Name=NOTCH3 {ECO:0000313|Ensembl:ENSP00000473138}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000473138, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000473138, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000473138} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC004257; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC004663; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; M0R3C9; -. DR jPOST; M0R3C9; -. DR PeptideAtlas; M0R3C9; -. DR PRIDE; M0R3C9; -. DR Ensembl; ENST00000601011; ENSP00000473138; ENSG00000074181. DR UCSC; uc060usd.1; human. DR EuPathDB; HostDB:ENSG00000074181.8; -. DR HGNC; HGNC:7883; NOTCH3. DR OpenTargets; ENSG00000074181; -. DR eggNOG; ENOG410IR7G; Eukaryota. DR eggNOG; COG0666; LUCA. DR GeneTree; ENSGT00940000160234; -. DR ChiTaRS; NOTCH3; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000074181; Expressed in 219 organ(s), highest expression level in vagina. DR ExpressionAtlas; M0R3C9; baseline and differential. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR Pfam; PF00008; EGF; 18. DR Pfam; PF07645; EGF_CA; 5. DR Pfam; PF12661; hEGF; 4. DR SMART; SM00181; EGF; 32. DR SMART; SM00179; EGF_CA; 28. DR SUPFAM; SSF57184; SSF57184; 5. DR PROSITE; PS00010; ASX_HYDROXYL; 17. DR PROSITE; PS00022; EGF_1; 30. DR PROSITE; PS01186; EGF_2; 22. DR PROSITE; PS50026; EGF_3; 31. DR PROSITE; PS01187; EGF_CA; 8. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00602928}; KW Proteomics identification {ECO:0000213|MaxQB:M0R3C9, KW ECO:0000213|PeptideAtlas:M0R3C9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 38 {ECO:0000256|SAM:SignalP}. FT CHAIN 39 1286 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004004167. FT DOMAIN 38 76 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 77 117 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 118 155 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 157 194 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 196 233 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 235 271 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 273 311 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 313 349 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 350 388 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 390 428 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 430 466 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 468 504 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 506 542 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 544 579 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 581 617 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 619 654 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 656 692 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 694 729 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 733 769 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 793 832 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 834 869 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 871 907 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 909 945 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 947 981 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 993 1029 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1031 1067 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1069 1105 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1107 1150 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1152 1191 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1193 1234 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1236 1272 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DISULFID 66 75 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 107 116 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 145 154 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 184 193 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 223 232 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 261 270 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 301 310 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 339 348 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 359 376 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 378 387 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 418 427 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 456 465 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 494 503 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 532 541 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 548 558 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 569 578 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 607 616 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 623 633 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 644 653 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 682 691 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 698 708 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 719 728 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 759 768 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 822 831 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 838 848 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 859 868 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 897 906 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 935 944 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 971 980 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1019 1028 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1057 1066 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1095 1104 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1140 1149 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1181 1190 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1224 1233 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1262 1271 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000473138}. FT NON_TER 1286 1286 {ECO:0000313|Ensembl:ENSP00000473138}. SQ SEQUENCE 1286 AA; 134318 MW; A43C93C04502FACF CRC64; GPGARGRRRR RRPMSPPPPP PPVRALPLLL LLAGPGAAAP PCLDGSPCAN GGRCTQLPSR EAACLCPPGW VGERCQLEDP CHSGPCAGRG VCQSSVVAGT ARFSCRCPRG FRGPDCSLPD PCLSSPCAHG ARCSVGPDGR FLCSCPPGYQ GRSCRSDVDE CRVGEPCRHG GTCLNTPGSF RCQCPAGYTG PLCENPAVPC APSPCRNGGT CRQSGDLTYD CACLPGFEGQ NCEVNVDDCP GHRCLNGGTC VDGVNTYNCQ CPPEWTGQFC TEDVDECQLQ PNACHNGGTC FNTLGGHSCV CVNGWTGESC SQNIDDCATA VCFHGATCHD RVASFYCACP MGKTGLLCHL DDACVSNPCH EDAICDTNPV NGRAICTCPP GFTGGACDQD VDECSIGANP CEHLGRCVNT QGSFLCQCGR GYTGPRCETD VNECLSGPCR NQATCLDRIG QFTCICMAGF TGTYCEVDID ECQSSPCVNG GVCKDRVNGF SCTCPSGFSG STCQLDVDEC ASTPCRNGAK CVDQPDGYEC RCAEGFEGTL CDRNVDDCSP DPCHHGRCVD GIASFSCACA PGYTGTRCES QVDECRSQPC RHGGKCLDLV DKYLCRCPSG TTGVNCEVNI DDCASNPCTF GVCRDGINRY DCVCQPGFTG PLCNVEINEC ASSPCGEGGS CVDGENGFRC LCPPGSLPPL CLPPSHPCAH EPCSHGICYD APGGFRCVCE PGWSGPRCSQ SLARDACESQ PCRAGGTCSS DGMGFHCTCP PGVQGRQCEL LSPCTPNPCE HGGRCESAPG QLPVCSCPQG WQDPCLNGGS CQDGVGSFSC SCLPGFAGPR CARDVDECLS NPCGPGTCTD HVASFTCTCP PGYGGFHCEQ DLPDCSPSSC FNGGTCVDGV NSFSCLCRPG YTGAHCQHEA DPCLSRPCLH GGVCSAAHPG FRCTCLESFT GPQCQTLVDW CSRQPCQNGG RCVQTGAYCL CPPGWSGRLC DIRSLPCREA AAQIGVRLEQ LCQAGGQCVD EDSSHYCVCP EGRTGSHCEQ EVDPCLAQPC QHGGTCRGYM GGYMCECLPG YNGDNCEDDV DECASQPCQH GGSCIDLVAR YLCSCPPGTL GVLCEINEDD CGPGPPLDSG PRCLHNGTCV DLVGGFRCTC PPGYTGLRCE ADINECRSGA CHAAHTRDCL QDPGGGFRCL CHAGFSGPRC QTVLSPCESQ PCQHGGQCRP SPGPGGGLTF TCHCAQPFWG PRCERVARSC RELQCPVGVP CQQTPRGPRC ACPPGLSGPS CRSFPGSPPG ASNASC //