ID   M0R2R8_HUMAN            Unreviewed;       137 AA.
AC   M0R2R8;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 41.
DE   SubName: Full=B-cell receptor CD22 {ECO:0000313|Ensembl:ENSP00000472762};
DE   Flags: Fragment;
GN   Name=CD22 {ECO:0000313|Ensembl:ENSP00000472762};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000472762, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000472762, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000472762}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
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DR   EMBL; AC002132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U62631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0R2R8; -.
DR   jPOST; M0R2R8; -.
DR   PeptideAtlas; M0R2R8; -.
DR   Ensembl; ENST00000597916; ENSP00000472762; ENSG00000012124.
DR   UCSC; uc060xbp.1; human.
DR   EuPathDB; HostDB:ENSG00000012124.14; -.
DR   HGNC; HGNC:1643; CD22.
DR   OpenTargets; ENSG00000012124; -.
DR   eggNOG; ENOG410IUGI; Eukaryota.
DR   eggNOG; ENOG410YH8H; LUCA.
DR   GeneTree; ENSGT00940000154722; -.
DR   ChiTaRS; CD22; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000012124; Expressed in 176 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; M0R2R8; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:M0R2R8,
KW   ECO:0000213|PeptideAtlas:M0R2R8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    137       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008421115.
FT   DOMAIN       27    134       IGv. {ECO:0000259|Pfam:PF07686}.
FT   NON_TER     137    137       {ECO:0000313|Ensembl:ENSP00000472762}.
SQ   SEQUENCE   137 AA;  16004 MW;  F0040ACB4C22B6AF CRC64;
     MHLLGPWLLL LEYLAFSDSS KWVFEHPETL YAWEGACVWI PCTYRALDGD LESFILFHNP
     EYNKNTSKFD GTRLYESTKD GKVPSEQKRV QFLGDKNKNC TLSIHPVHLN DSGQLGLRME
     SKTEKWMERI HLNVSER
//