ID   M0R2G8_HUMAN            Unreviewed;       165 AA.
AC   M0R2G8;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   SubName: Full=Cytochrome P450 2S1 {ECO:0000313|Ensembl:ENSP00000472555};
GN   Name=CYP2S1 {ECO:0000313|Ensembl:ENSP00000472555};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000472555, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000472555, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000472555}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
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DR   EMBL; AC011510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0R2G8; -.
DR   jPOST; M0R2G8; -.
DR   PeptideAtlas; M0R2G8; -.
DR   PRIDE; M0R2G8; -.
DR   Ensembl; ENST00000593545; ENSP00000472555; ENSG00000167600.
DR   UCSC; uc060yyw.1; human.
DR   EuPathDB; HostDB:ENSG00000167600.13; -.
DR   HGNC; HGNC:15654; CYP2S1.
DR   OpenTargets; ENSG00000167600; -.
DR   eggNOG; KOG0156; Eukaryota.
DR   eggNOG; COG2124; LUCA.
DR   GeneTree; ENSGT00940000162131; -.
DR   ChiTaRS; CYP2S1; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000167600; Expressed in 111 organ(s), highest expression level in jejunal mucosa.
DR   ExpressionAtlas; M0R2G8; baseline and differential.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:M0R2G8,
KW   ECO:0000213|PeptideAtlas:M0R2G8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    165       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004005354.
SQ   SEQUENCE   165 AA;  17781 MW;  B4CC0C7645A26692 CRC64;
     MEATGTWALL LALALLLLLT LALSGTRARG HLPPGPTPLP LLGNLLQLRP GALYSGLMRL
     SKKYGPVFTI YLGPWRPVVV LVGQEAVREA LGGQAEEFSG RGTVAMLEGT FDGHGGTKPR
     HRIHQQEHAD DSHLFAVCWD DDGQHHGRLY PPAPDEIPSC PKVGT
//