ID   M0R266_HUMAN            Unreviewed;       141 AA.
AC   M0R266;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=IgG receptor FcRn large subunit p51 {ECO:0000313|Ensembl:ENSP00000472350};
DE   Flags: Fragment;
GN   Name=FCGRT {ECO:0000313|Ensembl:ENSP00000472350};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000472350, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000472350, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000472350}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; M0R266; -.
DR   PeptideAtlas; M0R266; -.
DR   PRIDE; M0R266; -.
DR   Ensembl; ENST00000598491; ENSP00000472350; ENSG00000104870.
DR   UCSC; uc061bes.1; human.
DR   EuPathDB; HostDB:ENSG00000104870.12; -.
DR   HGNC; HGNC:3621; FCGRT.
DR   OpenTargets; ENSG00000104870; -.
DR   eggNOG; ENOG410IPRY; Eukaryota.
DR   eggNOG; ENOG4111C4R; LUCA.
DR   GeneTree; ENSGT00940000154232; -.
DR   ChiTaRS; FCGRT; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000104870; Expressed in 208 organ(s), highest expression level in mucosa of transverse colon.
DR   ExpressionAtlas; M0R266; baseline and differential.
DR   Gene3D; 3.30.500.10; -; 1.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   Pfam; PF00129; MHC_I; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:M0R266};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    141       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004306.
FT   DOMAIN       27    141       MHC_I-like_Ag-recog.
FT                                {ECO:0000259|Pfam:PF00129}.
FT   NON_TER     141    141       {ECO:0000313|Ensembl:ENSP00000472350}.
SQ   SEQUENCE   141 AA;  15498 MW;  E9C47BBC61772EF2 CRC64;
     MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS
     YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE
     LGPDNTSVPT AKFALNGEEF M
//