ID   M0R1Z7_HUMAN            Unreviewed;       172 AA.
AC   M0R1Z7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   05-DEC-2018, entry version 46.
DE   SubName: Full=Prostate-specific antigen {ECO:0000313|Ensembl:ENSP00000472213};
DE   Flags: Fragment;
GN   Name=KLK3 {ECO:0000313|Ensembl:ENSP00000472213};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000472213, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000472213, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000472213}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
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DR   EMBL; AC011523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0R1Z7; -.
DR   Allergome; 2836; Hom s PSA.
DR   PeptideAtlas; M0R1Z7; -.
DR   Ensembl; ENST00000601503; ENSP00000472213; ENSG00000142515.
DR   UCSC; uc061btf.1; human.
DR   EuPathDB; HostDB:ENSG00000142515.14; -.
DR   HGNC; HGNC:6364; KLK3.
DR   OpenTargets; ENSG00000142515; -.
DR   GeneTree; ENSGT00940000153418; -.
DR   ChiTaRS; KLK3; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000142515; Expressed in 122 organ(s), highest expression level in prostate gland.
DR   ExpressionAtlas; M0R1Z7; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
KW   Proteomics identification {ECO:0000213|MaxQB:M0R1Z7,
KW   ECO:0000213|PeptideAtlas:M0R1Z7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    172       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013062340.
FT   DOMAIN       18    172       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   NON_TER     172    172       {ECO:0000313|Ensembl:ENSP00000472213}.
SQ   SEQUENCE   172 AA;  19094 MW;  43EA2740DB5A2F4E CRC64;
     MWVPVVFLTL SVTWIAPPLQ VLVASRGRAV CGGVLVHPQW VLTAAHCIRN KSVILLGRHS
     LFHPEDTGQV FQVSHSFPHP LYDMSLLKNR FLRPGDDSSH DLMLLRLSEP AELTDAVKVM
     DLPTQEPALG TTCYASGWGS IEPEEFLTPK KLQCVDLHVI SNDVCAQVHP QK
//