ID   M0R1M2_HUMAN            Unreviewed;       225 AA.
AC   M0R1M2;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=B-cell receptor CD22 {ECO:0000313|Ensembl:ENSP00000471972};
DE   Flags: Fragment;
GN   Name=CD22 {ECO:0000313|Ensembl:ENSP00000471972};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471972, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000471972, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000471972}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
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DR   EMBL; AC002132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U62631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0R1M2; -.
DR   jPOST; M0R1M2; -.
DR   PeptideAtlas; M0R1M2; -.
DR   PRIDE; M0R1M2; -.
DR   Ensembl; ENST00000593867; ENSP00000471972; ENSG00000012124.
DR   UCSC; uc060xbs.1; human.
DR   EuPathDB; HostDB:ENSG00000012124.14; -.
DR   HGNC; HGNC:1643; CD22.
DR   OpenTargets; ENSG00000012124; -.
DR   eggNOG; ENOG410IUGI; Eukaryota.
DR   eggNOG; ENOG410YH8H; LUCA.
DR   GeneTree; ENSGT00940000154722; -.
DR   ChiTaRS; CD22; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000012124; Expressed in 176 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; M0R1M2; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00504776};
KW   Proteomics identification {ECO:0000213|MaxQB:M0R1M2,
KW   ECO:0000213|PeptideAtlas:M0R1M2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    225       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008421116.
FT   DOMAIN      143    225       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   NON_TER     225    225       {ECO:0000313|Ensembl:ENSP00000471972}.
SQ   SEQUENCE   225 AA;  25955 MW;  FDDAA0CB61DD81BA CRC64;
     MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD GDLESFILFH
     NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK NCTLSIHPVH LNDSGQLGLR
     MESKTEKWME RIHLNVSERP FPPHIQLPPE IQESQEVTLT CLLNFSCYGY PIQLQWLLEG
     VPMRQAAVTS TSLTIKSVFT RSELKFSPQW SHHGKIVTCQ LQDAD
//