ID   M0R177_HUMAN            Unreviewed;       220 AA.
AC   M0R177;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   05-DEC-2018, entry version 36.
DE   SubName: Full=Delta-like protein 3 {ECO:0000313|Ensembl:ENSP00000471688};
DE   Flags: Fragment;
GN   Name=DLL3 {ECO:0000313|Ensembl:ENSP00000471688};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471688, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000471688, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000471688}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC011500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0R177; -.
DR   PeptideAtlas; M0R177; -.
DR   Ensembl; ENST00000596614; ENSP00000471688; ENSG00000090932.
DR   UCSC; uc060ymq.1; human.
DR   EuPathDB; HostDB:ENSG00000090932.10; -.
DR   HGNC; HGNC:2909; DLL3.
DR   OpenTargets; ENSG00000090932; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; ENOG410XP6K; LUCA.
DR   GeneTree; ENSGT00940000162127; -.
DR   ChiTaRS; DLL3; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000090932; Expressed in 41 organ(s), highest expression level in nucleus accumbens.
DR   ExpressionAtlas; M0R177; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organism development; IEA:InterPro.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR011651; Notch_ligand_N.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF07657; MNNL; 1.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00179; EGF_CA; 1.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 3.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    220       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004005335.
FT   DOMAIN      125    161       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      163    199       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      201    220       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID    151    160       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    189    198       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   NON_TER     220    220       {ECO:0000313|Ensembl:ENSP00000471688}.
SQ   SEQUENCE   220 AA;  23117 MW;  6D151E6C33B005A1 CRC64;
     MVSPRMSGLL SQTVILALIF LPQTRPAGVF ELQIHSFGPG PGPGAPRSPC SARLPCRLFF
     RVCLKPGLSE EAAESPCALG AALSARGPVY TEQPGAPAPD LPLPDGLLQV PFRDAWPGTF
     SFIIETWREE LGDQIGGGLC LDLGHALRCR CRAGFAGPRC EHDLDDCAGR ACANGGTCVE
     GGGAHRCSCA LGFGGRDCRE RADPCAARPC AHGGRCYAHF
//