ID   M0R154_HUMAN            Unreviewed;        89 AA.
AC   M0R154;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   13-FEB-2019, entry version 36.
DE   SubName: Full=Endothelial cell-specific molecule 1 {ECO:0000313|Ensembl:ENSP00000471642};
DE   Flags: Fragment;
GN   Name=ESM1 {ECO:0000313|Ensembl:ENSP00000471642};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471642, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000471642, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000471642}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
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DR   EMBL; AC010436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC034238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0R154; -.
DR   PeptideAtlas; M0R154; -.
DR   PRIDE; M0R154; -.
DR   Ensembl; ENST00000601836; ENSP00000471642; ENSG00000164283.
DR   UCSC; uc063dot.1; human.
DR   EuPathDB; HostDB:ENSG00000164283.12; -.
DR   HGNC; HGNC:3466; ESM1.
DR   OpenTargets; ENSG00000164283; -.
DR   eggNOG; ENOG410IRWQ; Eukaryota.
DR   eggNOG; ENOG4111J6S; LUCA.
DR   GeneTree; ENSGT00390000018810; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000164283; Expressed in 95 organ(s), highest expression level in right lung.
DR   ExpressionAtlas; M0R154; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR   InterPro; IPR038850; ESM1.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR000867; IGFBP-like.
DR   PANTHER; PTHR15428; PTHR15428; 1.
DR   Pfam; PF00219; IGFBP; 1.
DR   SMART; SM00121; IB; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS51323; IGFBP_N_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:M0R154,
KW   ECO:0000213|PeptideAtlas:M0R154};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20     89       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004104.
FT   DOMAIN       24     89       IGFBP N-terminal.
FT                                {ECO:0000259|PROSITE:PS51323}.
FT   NON_TER      89     89       {ECO:0000313|Ensembl:ENSP00000471642}.
SQ   SEQUENCE   89 AA;  9514 MW;  D86F0334A163AB85 CRC64;
     MKSVLLLTTL LVPAHLVAAW SNNYAVDCPQ HCDSSECKSS PRCKRTVLDD CGCCRVCAAG
     RGETCYRTVS GMDGMKCGPG LRCQPSNGE
//