ID   M0R151_HUMAN            Unreviewed;       109 AA.
AC   M0R151;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   16-JAN-2019, entry version 39.
DE   SubName: Full=Kallikrein related peptidase 11 isoform 5 transcript variant 7 {ECO:0000313|EMBL:AUG68738.1};
DE   SubName: Full=Kallikrein-11 {ECO:0000313|Ensembl:ENSP00000471636};
GN   Name=KLK11 {ECO:0000313|EMBL:AUG68738.1,
GN   ECO:0000313|Ensembl:ENSP00000471636};
GN   Synonyms=TLSP {ECO:0000313|EMBL:AUG68738.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471636, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000471636, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000471636}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:AUG68738.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Adamopoulos P.G., Kontos C.K., Scorilas A.;
RT   "Discovery of novel transcripts of the human tissue kallikrein-related
RT   peptidase 11 (KLK11) genes in human cancer cells using Next-generation
RT   sequencing.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AC011473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; MG463108; AUG68738.1; -; mRNA.
DR   UniGene; Hs.57771; -.
DR   ProteinModelPortal; M0R151; -.
DR   jPOST; M0R151; -.
DR   PeptideAtlas; M0R151; -.
DR   PRIDE; M0R151; -.
DR   Ensembl; ENST00000600362; ENSP00000471636; ENSG00000167757.
DR   UCSC; uc061bvs.1; human.
DR   EuPathDB; HostDB:ENSG00000167757.13; -.
DR   HGNC; HGNC:6359; KLK11.
DR   OpenTargets; ENSG00000167757; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000153418; -.
DR   ChiTaRS; KLK11; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000167757; Expressed in 136 organ(s), highest expression level in ectocervix.
DR   ExpressionAtlas; M0R151; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:M0R151,
KW   ECO:0000213|PeptideAtlas:M0R151};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    109       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004139.
FT   DOMAIN        1    107       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
SQ   SEQUENCE   109 AA;  11979 MW;  60E146C03E44CA1B CRC64;
     MRILQLILLA LATVRLPHTL RCANITIIEH QKCENAYPGN ITDTMVCASV QEGGKDSCQG
     DSGGPLVCNQ SLQGIISWGQ DPCAITRKPG VYTKVCKYVD WIQETMKNN
//