ID   M0R0Y8_HUMAN            Unreviewed;       142 AA.
AC   M0R0Y8;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   05-DEC-2018, entry version 28.
DE   SubName: Full=Calreticulin-3 {ECO:0000313|Ensembl:ENSP00000471533};
DE   Flags: Fragment;
GN   Name=CALR3 {ECO:0000313|Ensembl:ENSP00000471533};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471533, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000471533, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000471533}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|SAAS:SAAS00583789}.
CC   -!- SIMILARITY: Belongs to the calreticulin family.
CC       {ECO:0000256|RuleBase:RU362126, ECO:0000256|SAAS:SAAS00583791}.
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DR   EMBL; AC008764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0R0Y8; -.
DR   PeptideAtlas; M0R0Y8; -.
DR   Ensembl; ENST00000600762; ENSP00000471533; ENSG00000269058.
DR   UCSC; uc060uzc.1; human.
DR   EuPathDB; HostDB:ENSG00000269058.5; -.
DR   HGNC; HGNC:20407; CALR3.
DR   OpenTargets; ENSG00000269058; -.
DR   GeneTree; ENSGT00940000153437; -.
DR   ChiTaRS; CALR3; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000269058; Expressed in 36 organ(s), highest expression level in testis.
DR   ExpressionAtlas; M0R0Y8; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   InterPro; IPR001580; Calret/calnex.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   PANTHER; PTHR11073; PTHR11073; 2.
DR   Pfam; PF00262; Calreticulin; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
PE   1: Evidence at protein level;
KW   Chaperone {ECO:0000256|RuleBase:RU362126};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU362126};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:M0R0Y8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU362126}.
FT   SIGNAL        1     16       {ECO:0000256|RuleBase:RU362126}.
FT   CHAIN        17    142       {ECO:0000256|RuleBase:RU362126}.
FT                                /FTId=PRO_5005139418.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000471533}.
FT   NON_TER     142    142       {ECO:0000313|Ensembl:ENSP00000471533}.
SQ   SEQUENCE   142 AA;  16691 MW;  A0EA19187D742616 CRC64;
     XLVQLWAICM LRVALATVYF QEEFLDGEHW RNRWLQSTND SRFGHFRLSS GKFYGHKEKD
     KGPDICGFDI KKVHVILHFK NKYHENKKLI RCKVDGFTHL YTLILRPDLS YDVKIDGQSI
     ESGSIEYDWN LTSLKKETSP AE
//