ID   M0R0X2_HUMAN            Unreviewed;       143 AA.
AC   M0R0X2;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   12-SEP-2018, entry version 39.
DE   SubName: Full=Neurotrophin-4 {ECO:0000313|Ensembl:ENSP00000471508};
DE   Flags: Fragment;
GN   Name=NTF4 {ECO:0000313|Ensembl:ENSP00000471508};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471508, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000471508, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000471508}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|SAAS:SAAS00543519}.
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DR   EMBL; AC008687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0R0X2; -.
DR   PRIDE; M0R0X2; -.
DR   Ensembl; ENST00000595857; ENSP00000471508; ENSG00000225950.
DR   UCSC; uc061aza.1; human.
DR   EuPathDB; HostDB:ENSG00000225950.7; -.
DR   HGNC; HGNC:8024; NTF4.
DR   OpenTargets; ENSG00000225950; -.
DR   eggNOG; ENOG410IIFY; Eukaryota.
DR   eggNOG; ENOG4111839; LUCA.
DR   GeneTree; ENSGT00390000007725; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000225950; Expressed in 65 organ(s), highest expression level in skin of abdomen.
DR   ExpressionAtlas; M0R0X2; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR020432; Neurotrophin-4.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF8; PTHR11589:SF8; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 2.
DR   PRINTS; PR01915; NEUROTROPHN4.
DR   PRINTS; PR00268; NGF.
DR   ProDom; PD002052; Nerve_growth_factor-rel; 1.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00022131};
KW   Growth factor {ECO:0000256|SAAS:SAAS00426801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    143       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004103.
FT   DOMAIN       89    143       NGF. {ECO:0000259|SMART:SM00140}.
FT   NON_TER     143    143       {ECO:0000313|Ensembl:ENSP00000471508}.
SQ   SEQUENCE   143 AA;  15255 MW;  B2577B59EFF30CAC CRC64;
     MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR GAPAGPPLLF
     LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV
     LGEVPAAGGS PLRQYFFETR CKA
//