ID   M0R0K5_HUMAN            Unreviewed;       831 AA.
AC   M0R0K5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   16-JAN-2019, entry version 51.
DE   SubName: Full=Adhesion G protein-coupled receptor E2 {ECO:0000313|Ensembl:ENSP00000471297};
GN   Name=ADGRE2 {ECO:0000313|Ensembl:ENSP00000471297};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471297, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000471297, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000471297}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|SAAS:SAAS00547938}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC005327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0R0K5; -.
DR   EPD; M0R0K5; -.
DR   jPOST; M0R0K5; -.
DR   MaxQB; M0R0K5; -.
DR   PeptideAtlas; M0R0K5; -.
DR   PRIDE; M0R0K5; -.
DR   Ensembl; ENST00000601345; ENSP00000471297; ENSG00000127507.
DR   UCSC; uc031rju.2; human.
DR   EuPathDB; HostDB:ENSG00000127507.17; -.
DR   HGNC; HGNC:3337; ADGRE2.
DR   OpenTargets; ENSG00000127507; -.
DR   eggNOG; KOG4193; Eukaryota.
DR   eggNOG; ENOG410XSD2; LUCA.
DR   GeneTree; ENSGT00940000162597; -.
DR   OMA; LTFKFCR; -.
DR   ChiTaRS; ADGRE2; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000127507; Expressed in 120 organ(s), highest expression level in blood.
DR   ExpressionAtlas; M0R0K5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR003056; GPCR_2_CD97.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF07645; EGF_CA; 4.
DR   Pfam; PF01825; GPS; 1.
DR   PRINTS; PR01278; CD97PROTEIN.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00181; EGF; 5.
DR   SMART; SM00179; EGF_CA; 4.
DR   SMART; SM00303; GPS; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 4.
DR   PROSITE; PS50026; EGF_3; 4.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00909960};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:M0R0K5,
KW   ECO:0000213|PeptideAtlas:M0R0K5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    831       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004097.
FT   TRANSMEM    527    550       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    562    579       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    591    615       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    635    653       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    673    699       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    719    741       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    747    770       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       67    106       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      119    162       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      163    201       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      212    250       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      468    518       GPS. {ECO:0000259|PROSITE:PS50221}.
FT   DOMAIN      525    771       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
SQ   SEQUENCE   831 AA;  91323 MW;  DB7F643C7677C200 CRC64;
     MGGRVFLVFL AFCVWLTLPG AETQDSRGCA RWCPQDSSCV NATACRCNPG FSSFSEIITT
     PMETCDDINE CATLSKVSCG KFSDCWNTEG SYDCVCSPGY EPVSGAKTFK NESENTCQDV
     DECQQNPRLC KSYGTCVNTL GSYTCQCLPG FKLKPEDPKL CTDVNECTSG QNPCHSSTHC
     LNNVGSYQCR CRPGWQPIPG SPNGPNNTVC EDVDECSSGQ HQCDSSTVCF NTVGSYSCRC
     RPGWKPRHGI PNNQKDTVCE DMTFSTWTPP PGVHSQTLSR FFDKVQDLGR DYKPGLANNT
     IQSILQALDE LLEAPGDLET LPRLQQHCVA SHLLDGLEDV LRGLSKNLSN GLLNFSYPAG
     TELSLEVQKQ VDRSVTLRQN QAVMQLDWNQ AQKSGDPGMG KLLAEAPLVL EPEKQMLLHE
     THQGLLQDGS PILLSDVISA FLSNNDTQNL SSPVTFTFSH RSVIPRQKVL CVFWEHGQNG
     CGHWATTGCS TIGTRDTSTI CRCTHLSSFA VLMAHYDVQE EDPVLTVITY MGLSVSLLCL
     LLAALTFLLC KAIQNTSTSL HLQLSLCLFL AHLLFLVAID QTGHKVLCSI IAGTLHYLYL
     ATLTWMLLEA LYLFLTARNL TVVNYSSINR FMKKLMFPVG YGVPAVTVAI SAASRPHLYG
     TPSRCWLQPE KGFIWGFLGP VCAIFSVNLV LFLVTLWILK NRLSSLNSEV STLRNTRMLA
     FKATAQLFIL GCTWCLGILQ VGPAARVMAY LFTIINSLQG VFIFLVYCLL SQQVREQYGK
     WSKGIRKLKT ESEMHTLSSS AKADTSKPST PGTVVQACNA STLGGQSRKI T
//