ID   M0R057_HUMAN            Unreviewed;       187 AA.
AC   M0R057;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   SubName: Full=Cytochrome P450 2S1 {ECO:0000313|Ensembl:ENSP00000471016};
DE   Flags: Fragment;
GN   Name=CYP2S1 {ECO:0000313|Ensembl:ENSP00000471016};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000471016, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000471016, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000471016}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
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DR   EMBL; AC011510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0R057; -.
DR   SMR; M0R057; -.
DR   jPOST; M0R057; -.
DR   PeptideAtlas; M0R057; -.
DR   PRIDE; M0R057; -.
DR   Ensembl; ENST00000600561; ENSP00000471016; ENSG00000167600.
DR   UCSC; uc060yyx.1; human.
DR   EuPathDB; HostDB:ENSG00000167600.13; -.
DR   HGNC; HGNC:15654; CYP2S1.
DR   OpenTargets; ENSG00000167600; -.
DR   eggNOG; KOG0156; Eukaryota.
DR   eggNOG; COG2124; LUCA.
DR   GeneTree; ENSGT00940000162131; -.
DR   ChiTaRS; CYP2S1; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000167600; Expressed in 111 organ(s), highest expression level in jejunal mucosa.
DR   ExpressionAtlas; M0R057; baseline and differential.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:M0R057,
KW   ECO:0000213|PeptideAtlas:M0R057};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    187       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004292.
FT   NON_TER     187    187       {ECO:0000313|Ensembl:ENSP00000471016}.
SQ   SEQUENCE   187 AA;  20496 MW;  D7EC166B2EFBBEF2 CRC64;
     MEATGTWALL LALALLLLLT LALSGTRARG HLPPGPTPLP LLGNLLQLRP GALYSGLMRL
     SKKYGPVFTI YLGPWRPVVV LVGQEAVREA LGGQAEEFSG RGTVAMLEGT FDGHGVFFSN
     GERWRQLRKF TMLALRDLGM GKREGEELIQ AEARCLVETF QGTEGGTKPR HRIHQQEHAD
     DSHLFAV
//