ID   M0QZX2_HUMAN            Unreviewed;       488 AA.
AC   M0QZX2;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   05-DEC-2018, entry version 24.
DE   SubName: Full=Transmembrane protein 145 {ECO:0000313|Ensembl:ENSP00000470827};
GN   Name=TMEM145 {ECO:0000313|Ensembl:ENSP00000470827};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000470827, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000470827, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000470827}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
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DR   EMBL; AC024078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0QZX2; -.
DR   PeptideAtlas; M0QZX2; -.
DR   PRIDE; M0QZX2; -.
DR   Ensembl; ENST00000598766; ENSP00000470827; ENSG00000167619.
DR   UCSC; uc060zgx.1; human.
DR   EuPathDB; HostDB:ENSG00000167619.11; -.
DR   HGNC; HGNC:26912; TMEM145.
DR   OpenTargets; ENSG00000167619; -.
DR   GeneTree; ENSGT00940000153981; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000167619; Expressed in 82 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; M0QZX2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR   InterPro; IPR019336; Intimal_thickness-rel_rcpt.
DR   Pfam; PF10192; GpcrRhopsn4; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    488       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004005318.
FT   TRANSMEM    199    219       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    231    253       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    265    284       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    304    321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    341    359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    371    395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    415    438       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      168    421       GpcrRhopsn4. {ECO:0000259|Pfam:PF10192}.
SQ   SEQUENCE   488 AA;  56157 MW;  C929FD289809448D CRC64;
     MEPLRAPALR RLLPPLLLLL LSLPPRARAK YVRGNLSSKE DWVFLTRFCF LSDYGRLDFR
     FRYPELPVPN ISGLQAKCCQ NILLYFDDPS QWPAVYKAGD KDCLAKESVI RPENNQVINL
     TTQYAWSGCQ VVSEEGTRYL SCSSGRSFRS VRERWWYIAL SKCGGDGLQL EYEMVLTNGK
     SFWTRHFSAD EFGILETDVT FLLIFILIFF LSCYFGYLLK GRQLLHTTYK MFMAAAGVEV
     LSLLFFCIYW GQYATDGIGN ESVKILAKLL FSSSFLIFLL MLILLGKGFT VTRGRISHAG
     SVKLSVYMTL YTLTHVVLLI YEAEFFDPGQ VLYTYESPAG YGLIGLQVAA YVWFCYAVLV
     SLRHFPEKQP FYVPFFAAYT LWFFAVPVMA LIANFGIPKW AREKIVNGIQ LGIHLYAHGV
     FLILPFLFCI PTAFPTLLDL STLPLPLPKF CHHRPLFRKK HLGWHRVKLL GSWVGNRRVQ
     HHIFFFFF
//