ID   M0QZG6_HUMAN            Unreviewed;       172 AA.
AC   M0QZG6;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   16-JAN-2019, entry version 28.
DE   SubName: Full=Lysosomal alpha-mannosidase {ECO:0000313|Ensembl:ENSP00000470533};
DE   Flags: Fragment;
GN   Name=MAN2B1 {ECO:0000313|Ensembl:ENSP00000470533};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000470533, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000470533, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000470533}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC010422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0QZG6; -.
DR   jPOST; M0QZG6; -.
DR   MaxQB; M0QZG6; -.
DR   PeptideAtlas; M0QZG6; -.
DR   PRIDE; M0QZG6; -.
DR   Ensembl; ENST00000598876; ENSP00000470533; ENSG00000104774.
DR   UCSC; uc060uab.1; human.
DR   EuPathDB; HostDB:ENSG00000104774.12; -.
DR   HGNC; HGNC:6826; MAN2B1.
DR   OpenTargets; ENSG00000104774; -.
DR   GeneTree; ENSGT00940000154771; -.
DR   ChiTaRS; MAN2B1; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000104774; Expressed in 95 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; M0QZG6; baseline and differential.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.110.10; -; 1.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SUPFAM; SSF88713; SSF88713; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     49       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        50    172       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004127.
FT   DOMAIN       73    172       Glyco_hydro_38N.
FT                                {ECO:0000259|Pfam:PF01074}.
FT   NON_TER     172    172       {ECO:0000313|Ensembl:ENSP00000470533}.
SQ   SEQUENCE   172 AA;  19067 MW;  1FECF496718891B0 CRC64;
     MGAYARASGV CARGCLDSAG PWTMSRALRP PLPPLCFFLL LLAAAGARAG GYEVCVFGVP
     VQTCPTVQPN MLNVHLLPHT HDDVGWLKTV DQYFYGIKND IQHAGVQYIL DSVISALLAD
     PTRRFIYVEI AFFSRWWHQQ TNATQEVVRD LVRQGRLEFA NGGWVMNDEA AT
//