ID   M0QZF9_HUMAN            Unreviewed;       172 AA.
AC   M0QZF9;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   05-DEC-2018, entry version 40.
DE   SubName: Full=Prostate-specific antigen {ECO:0000313|Ensembl:ENSP00000470523};
DE   Flags: Fragment;
GN   Name=KLK3 {ECO:0000313|Ensembl:ENSP00000470523};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000470523, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000470523, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000470523}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
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DR   EMBL; AC011523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0QZF9; -.
DR   Allergome; 2836; Hom s PSA.
DR   PeptideAtlas; M0QZF9; -.
DR   PRIDE; M0QZF9; -.
DR   Ensembl; ENST00000597286; ENSP00000470523; ENSG00000142515.
DR   UCSC; uc061btk.1; human.
DR   EuPathDB; HostDB:ENSG00000142515.14; -.
DR   HGNC; HGNC:6364; KLK3.
DR   OpenTargets; ENSG00000142515; -.
DR   GeneTree; ENSGT00940000153418; -.
DR   ChiTaRS; KLK3; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000142515; Expressed in 122 organ(s), highest expression level in prostate gland.
DR   ExpressionAtlas; M0QZF9; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
KW   Proteomics identification {ECO:0000213|MaxQB:M0QZF9,
KW   ECO:0000213|PeptideAtlas:M0QZF9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    172       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004082.
FT   DOMAIN        1    172       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   NON_TER     172    172       {ECO:0000313|Ensembl:ENSP00000470523}.
SQ   SEQUENCE   172 AA;  19090 MW;  4393CB3108465B68 CRC64;
     MWVPVVFLTL AVCGGVLVHP QWVLTAAHCI RNKSVILLGR HSLFHPEDTG QVFQVSHSFP
     HPLYDMSLLK NRFLRPGDDS SHDLMLLRLS EPAELTDAVK VMDLPTQEPA LGTTCYASGW
     GSIEPEEFLT PKKLQCVDLH VISNDVCAQV HPQKVTKFML CAGRWTGGKS TC
//