ID   M0QZD8_HUMAN            Unreviewed;      3266 AA.
AC   M0QZD8;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 3.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000470478};
GN   Name=LOC400499 {ECO:0000313|Ensembl:ENSP00000470478};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000470478, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000470478, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000470478}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
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DR   EMBL; AC009121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC099489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF573656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0QZD8; -.
DR   BioMuta; ENSG00000188897; -.
DR   jPOST; M0QZD8; -.
DR   PeptideAtlas; M0QZD8; -.
DR   PRIDE; M0QZD8; -.
DR   Ensembl; ENST00000598234; ENSP00000470478; ENSG00000188897.
DR   UCSC; uc059qvd.1; human.
DR   EuPathDB; HostDB:ENSG00000188897.8; -.
DR   GeneCards; LOC400499; -.
DR   OpenTargets; ENSG00000188897; -.
DR   eggNOG; ENOG410IRRT; Eukaryota.
DR   eggNOG; ENOG410XR10; LUCA.
DR   GeneTree; ENSGT00440000038757; -.
DR   InParanoid; M0QZD8; -.
DR   OMA; LWDGQEV; -.
DR   ChiTaRS; LOC400499; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000188897; Expressed in 165 organ(s), highest expression level in blood.
DR   ExpressionAtlas; M0QZD8; baseline and differential.
DR   GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR   GO; GO:0071391; P:cellular response to estrogen stimulus; IBA:GO_Central.
DR   GO; GO:0032355; P:response to estradiol; IBA:GO_Central.
DR   Gene3D; 1.25.10.20; -; 1.
DR   Gene3D; 2.30.230.10; -; 1.
DR   InterPro; IPR015819; Lipid_transp_b-sht_shell.
DR   InterPro; IPR001747; Lipid_transpt_N.
DR   InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR   InterPro; IPR015816; Vitellinogen_b-sht_N.
DR   InterPro; IPR015255; Vitellinogen_open_b-sht.
DR   InterPro; IPR001846; VWF_type-D.
DR   Pfam; PF09172; DUF1943; 1.
DR   Pfam; PF01347; Vitellogenin_N; 1.
DR   SMART; SM01169; DUF1943; 1.
DR   SMART; SM00638; LPD_N; 1.
DR   SUPFAM; SSF48431; SSF48431; 1.
DR   SUPFAM; SSF56968; SSF56968; 2.
DR   PROSITE; PS51211; VITELLOGENIN; 1.
DR   PROSITE; PS51233; VWFD; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   3266       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017363557.
FT   DOMAIN       47    654       Vitellogenin.
FT                                {ECO:0000259|PROSITE:PS51211}.
FT   DOMAIN     3014   3218       VWFD. {ECO:0000259|PROSITE:PS51233}.
SQ   SEQUENCE   3266 AA;  357809 MW;  3B59F30D72B8E1B4 CRC64;
     MPAPVGLLGL VLLWPLMAVT AEKIPDSQVG QVASCMTACT GSAGPHLPVG TRYTYHFSTN
     TSTSLQDVLV EGSGLGLQGL AVLDVLGLCQ MALWLQDFQV TSILGAKVEL LKESESLSAT
     LGRNPLRFIL HSGRVAHLCP HPTEPRWVLN VKRAVLSLLQ GHPGAHSPKT FDEVDILGRC
     PTTYQHHGDW LHKTKDLARC SLRRGRSSLH SQALPGVAPG LTSRLTCVQS FRAGVLREAS
     CTELDSAGPL PAKASAVQMR TLSSLSLLHE MPQDPAGTDP DDRDDEDMTP SSLLYEWEET
     PSQAMVATAA TLVRRLCLAQ TTSLEAMDLF LTLVSQLQGL SGGELMELWQ YSSFKCRDNG
     QPLLDALPSC GTEHCVGLMK ELIASAAVEA DEVEAWLSSL AFLPQPTDAM VHMLLPLLQT
     PRASPGAFLG ISALVHNLCA SLDGPCGQLP GVGSLVRILG DALGENCTIQ EPSDDDKLQL
     VLKAVGNAGL AAMALTPTLS ACASLRSSTP EIRLGAIQAF RRVPCSADRS VLSRLYQSLE
     EDAEIRINAY LALMRCPSEE VFAQVRRTQA GELSTQVGSF VWSHILQLLE THDPLKRALR
     DTLPEDILSQ EFHPEMWKHS SYSDVTFRSV SGSLGANLEG TLLFSPASFL PRSATVNLTI
     HTMGRAFNLL ELGLRLENAE EIAHRLFGRK SFWGQEDGRE PEPEEPPGPE PGPAPQPASP
     ECPGDRDRRM RYLQQKVTRR RGARQALRCE LSVKLLGQEL SFVNCGATGS HVNHWPLNLA
     ELAIKLMKGQ EVQMNRRLSL AAQELVFPTV SGLPARLTLN ASAAISIRVR GTTDFQQRSD
     FSVNGYVKPS ALLQISAQMG TAGILGQAGL RWVTSVRSAA SLDGGIQVQK GRVLKVHLNT
     PEEAVELLSF SSQLYLITRD GVRSLRHVPG PSEVQSCTGE EVSYTWGWRL CTGVTWPVPG
     QPYLLSLPVF AAVTLQKRDP GLRQYLLEAA YTLQPQKGSW FPQEATAHVF MGTPGSEVLR
     DVGVDMSYSL PQNKFRLKLL HPKKKIELDG KMEALGSAHT GHLELVLDDR DVYYIKGWSD
     LQPAMGGEAE RFQAQLEVKL VTGGSPVVFT GNLTRQVGSK LAFSASLSHL LSDQANVTAL
     LERKEENGRR VAALGAELFV PGLVGLRALG LLQQRGQLWT NSLRIQYSLL GQAKQAAHEC
     STSQKLRADS GSDGAYRLEL RHELHCTQIL AFSHKVQLWH EEDSGHLHSQ LEVSYGKHWD
     KNSNKRHLRV SQTFKNDSGP ALSNHFMEFV LQVPERQVDC RVQLYHLSLR LPYVESSSHL
     KVQYNGRPLF VAGGQWKDTS RATLWKWEGA LNLDSPWLMV SAAHRLYWPH RAVFQAVLEL
     TLGKAWTLKD LVVSVGCRSQ GPNREGKIQV YTAATTYLRV STVTVLAQSL FHSWSELESA
     WNAAVQGEIH AENSRDRKIL NCWLKGPQQE LNLTAAYRHL EWPRKTQVSL TAVRIGAQGQ
     PRGLQLEGEL EELRQDRTLY RKRGALLLRH PLHLPIPQSL LLQETFTADR RHQRYSLETR
     VVLNGREETL QTMVLGCQAG HPYVCAGLMH PYDGKVIPRN TEGCLVTWNQ HTAKNREVEA
     TLKVHRKVVL HLKGLHHDRS QHGEIRHSLA LDLAHSYQLS FPQALSLDGG IIFRQSPQGT
     FNFGMDARAA VNHNVTSQAS VQLNGSDSDF AFFFQLRHPH GPTFPPNFQV QAAAGRYRVR
     SLNGSLSVQM SGRELVLLEV DASQDTRRSS RGWGVSVLLH QAVLSAPRAV RLQLSAKITP
     ARIWLFSKAL LDQNTAQLLL KASEEWRGGR ILTFQSQTRH TVAGWAAMPR LLTLTGRLKQ
     KETLQEGTLS VTADSAVLGF LLRDQHEKAG NGTSVRSVTC VLAQNSSQAL PGELQLKGRL
     QAQTRNLRAQ ASIRAHAASL ALGGACSWGP RHGQLAGGPT HNISTLSDAG LPSEAGMLLS
     LTHVASNCSA RLALWNAGAQ LDGAIGLEDV TPESSGLQLH ASLRHTHTMP SLKHWGLPFS
     LDGHGHFQVN CSGDASPTQL LGWCRGDIAG QPLEVSVDIH NGSSGFEHSG RILMGPTFLN
     YSVSCYYHDG HLELSGRSWH NSEALLWAGF PGEACLSAEL QIHETQTQAR VALHGGDSGV
     SMDLAALVAR PRRGPLQLVA SASHTVPALQ RLGLPFTNQL VFQGLWEAEE MSSSLQLTCD
     SQATLVLDVR GQNQAVSKEL LFSGRHRLPF LLGLCPSSAS ASAKLHYSKG EVQSMFALGV
     EERHFHISTR QVAAKAGLNN FIKLEQTFLQ LSALPRELFL QTAYERAHGT RVLRQVVLWD
     GQEVALTGSL SGPFPKPTRN LSLQVELTHP LPLPLPRHCS LRLSSEHLGG SHRDGLVVGW
     DGRDQVLVSS SLWLGKSELA ARLALAHPFN LPWRQAEASG LAESRGGRQS RQVQLTWNRG
     QPATLQLTWA DGSLAHSTAW DGCLAASPGQ LQETWGLNSL QACGAFTQTP AVFVEQLNVS
     WGQHRMRQNL TYERHWPSQP DKIIMEATLE HVLGASCTRQ SFWGEVQTDY ARWLRHSLHL
     GLCDLPRALL VVGEHTLGQG GLLLRSRCHL GLAPDPDHGL HLSLTLQNHS RPRSADFSGA
     LELRGSKAQR VGLLGRVSTS TSQSLVRLEG SVDNREEKVR LSVFRAPSCL QASVAHEEGG
     REESVVLRAC AHGRTAEAEV LFRDGRQPSQ PLGRLTLQAA NQSLLLAARG CQGGLLGHVE
     SRIAAVGSQV QARLEEKVQG LGASVRRFQQ LVQPAGTLDG VAGLLLQLSQ AGREAMQASG
     WAVATLWARS QALTQHLPLY LEWLQVGLEQ LREELEWPLA TLKDAYLEVT LRPLEEVWRE
     RAEEAMRRLQ AWVPGMPGKG GPRPIRAALG AMKGALELAA QQMLSWAEAT FSRALKRLCK
     PLLDLYSLSA RNRSVVVMLP LLPAGDEPLD VARVTSYLME EKLLRPLREL SGANVLAEYY
     WLRRRLLAGP WEYHALVAGA QHVVTFDGRV WDLSTQCGSI LLAQDFAHNT FSLTLSRTGS
     GLTALFVELN HKTLILYPSL QAYRLYNSSL PGDSCPDLKL HPATTRKDVS RIELASEDGV
     SVSCDVPTGL CSLTLGLWQH GISAGLLGTN DNEAGNELML PDGSMARSLE ELSLAWQVGG
     DCRATEKPQQ EQACPGQLPA CWAFFEGPHS SLRDCFRVVD PTPFLSLCVQ VPCGTQELQP
     ACNLAAAYIH LCARGFVPLA PPPQCV
//