ID   M0QZ43_HUMAN            Unreviewed;       676 AA.
AC   M0QZ43;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   12-SEP-2018, entry version 34.
DE   SubName: Full=Sarcoplasmic reticulum histidine-rich calcium-binding protein {ECO:0000313|Ensembl:ENSP00000470288};
GN   Name=HRC {ECO:0000313|Ensembl:ENSP00000470288};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000470288, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000470288, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [3] {ECO:0000313|Ensembl:ENSP00000470288}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC008891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0QZ43; -.
DR   PeptideAtlas; M0QZ43; -.
DR   PRIDE; M0QZ43; -.
DR   Ensembl; ENST00000595625; ENSP00000470288; ENSG00000130528.
DR   UCSC; uc061bac.1; human.
DR   EuPathDB; HostDB:ENSG00000130528.11; -.
DR   HGNC; HGNC:5178; HRC.
DR   OpenTargets; ENSG00000130528; -.
DR   eggNOG; ENOG410J2C1; Eukaryota.
DR   eggNOG; ENOG41122Z9; LUCA.
DR   GeneTree; ENSGT00730000111459; -.
DR   ChiTaRS; HRC; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000130528; Expressed in 108 organ(s), highest expression level in apex of heart.
DR   ExpressionAtlas; M0QZ43; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR019552; Hist_rich_Ca-bd.
DR   InterPro; IPR015666; HRC.
DR   PANTHER; PTHR15054; PTHR15054; 4.
DR   Pfam; PF10529; Hist_rich_Ca-bd; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:M0QZ43,
KW   ECO:0000213|PeptideAtlas:M0QZ43};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    676       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004279.
FT   COILED      527    557       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   676 AA;  77572 MW;  6336D5649F7D4608 CRC64;
     MGHHRPWLHA SVLWAGVASL LLPPAMTQQL RGDGLGFRNR NNSTGVAGLS EEASAELRHH
     LHSPRDHPDE NKDVSTENGH HFWSHPDREK EDEDVSKEYG HLLPGHRSQD HKVGDEGVSG
     EEVFAEHGGQ ARGHRGHGSE DTEDSAEHRH HLPSHRSHSH QDEDEDEVVS SEHHHHILRH
     GHRGHDGEDD EGEEEEEEEE EEEEASTEYG HQAHRHRGHG SEEDEDVSDG HHHHGPSHRH
     QGHEEDDDDD DDDDDDDDDD DVSIEYRHQA HRHQGHGIEE DEDVSDGHHH RDPSHRHRSH
     EEDDNDDDDV STEYGHQAHR HQDHRKEEVE AVSGEHHHHV PDHRHQGHRD EEEDEDVSTE
     RWHQGPQHVH HGLVDEEEEE EEITVQFGHY VASHQPRGHK SDEEDFQDEY KTEVPHHHHH
     RVPREEDEEV SAELGHQAPS HRQSHQDEET GHGQRGSIKE MSHHPPGHTV VKDRSHLRKD
     DSEEEKEKEE DPGSHEEDDE SSEQGEKGTH HGSRDQEDEE DEEEGHGLSL NQEEEEEEDK
     EEEEEEEDEE RREERAEVGA PLSPDHSEEE EEEEEGLEED EPRFTIIPNP LDRREEAGGA
     SSEEESGEDT GPQDAQEYGN YQPGSLCGYC SFCNHCQFCY LCPLVCETVC APGSYVDYFS
     SSLYQALADM LETPEP
//