ID   M0QYZ1_HUMAN            Unreviewed;       164 AA.
AC   M0QYZ1;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Lysosomal alpha-mannosidase {ECO:0000313|Ensembl:ENSP00000470174};
DE   Flags: Fragment;
GN   Name=MAN2B1 {ECO:0000313|Ensembl:ENSP00000470174};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000470174, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000470174, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000470174}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
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DR   EMBL; AC010422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0QYZ1; -.
DR   EPD; M0QYZ1; -.
DR   jPOST; M0QYZ1; -.
DR   PeptideAtlas; M0QYZ1; -.
DR   PRIDE; M0QYZ1; -.
DR   Ensembl; ENST00000486847; ENSP00000470174; ENSG00000104774.
DR   UCSC; uc060tzy.1; human.
DR   EuPathDB; HostDB:ENSG00000104774.12; -.
DR   HGNC; HGNC:6826; MAN2B1.
DR   OpenTargets; ENSG00000104774; -.
DR   eggNOG; KOG1959; Eukaryota.
DR   eggNOG; ENOG410XQMZ; LUCA.
DR   GeneTree; ENSGT00940000154771; -.
DR   ChiTaRS; MAN2B1; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000104774; Expressed in 95 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; M0QYZ1; baseline and differential.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.110.10; -; 1.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SUPFAM; SSF88713; SSF88713; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:M0QYZ1,
KW   ECO:0000213|MaxQB:M0QYZ1, ECO:0000213|PeptideAtlas:M0QYZ1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     49       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        50    164       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008421109.
FT   DOMAIN      107    162       Glyco_hydro_38N.
FT                                {ECO:0000259|Pfam:PF01074}.
FT   NON_TER     164    164       {ECO:0000313|Ensembl:ENSP00000470174}.
SQ   SEQUENCE   164 AA;  18032 MW;  D6417EDAB7147E81 CRC64;
     MGAYARASGV CARGCLDSAG PWTMSRALRP PLPPLCFFLL LLAAAGARAG GYESRMTSST
     PVCSTSWTRS SLPCWQIPPV ASFTWRLPSS PVGGTSRQMP HRKSCETLCA RMGFDGFFFG
     RLDYQDKWVR MQKLEMEQVW RASTSLKPPT ADLFTGVLPN GYNP
//