ID   M0QYM9_HUMAN            Unreviewed;       217 AA.
AC   M0QYM9;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   16-JAN-2019, entry version 36.
DE   SubName: Full=Fms-related tyrosine kinase 3 ligand {ECO:0000313|Ensembl:ENSP00000469942};
GN   Name=FLT3LG {ECO:0000313|Ensembl:ENSP00000469942};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000469942, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000469942, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000469942}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
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DR   EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005258737.3; XM_005258680.4.
DR   RefSeq; XP_005258738.3; XM_005258681.4.
DR   UniGene; Hs.428; -.
DR   ProteinModelPortal; M0QYM9; -.
DR   SMR; M0QYM9; -.
DR   PeptideAtlas; M0QYM9; -.
DR   Ensembl; ENST00000596435; ENSP00000469942; ENSG00000090554.
DR   GeneID; 2323; -.
DR   UCSC; uc061bdp.1; human.
DR   CTD; 2323; -.
DR   EuPathDB; HostDB:ENSG00000090554.12; -.
DR   HGNC; HGNC:3766; FLT3LG.
DR   OpenTargets; ENSG00000090554; -.
DR   GeneTree; ENSGT00530000064424; -.
DR   OrthoDB; 1596773at2759; -.
DR   ChiTaRS; FLT3LG; human.
DR   GenomeRNAi; 2323; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000090554; Expressed in 88 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; M0QYM9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR004213; Flt3_lig.
DR   PANTHER; PTHR11032; PTHR11032; 1.
DR   Pfam; PF02947; Flt3_lig; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    217       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004059.
FT   TRANSMEM    168    188       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   217 AA;  24364 MW;  1B8BD382CE3950F6 CRC64;
     MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD YLLQDYPVTV
     ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER VNTEIHFVTK CAFQETSEQL
     VALKPWITRQ NFSRCLELQC QPDSSTLPPP WSPRPLEATA PTAPQPPLLL LLLLPVGLLL
     LAAAWCLHWQ RTRRRTPRPG EQVPPVPSPQ DLLLVEH
//