ID   M0QXC5_HUMAN            Unreviewed;       268 AA.
AC   M0QXC5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   05-DEC-2018, entry version 42.
DE   SubName: Full=Napsin-A {ECO:0000313|Ensembl:ENSP00000469061};
DE   Flags: Fragment;
GN   Name=NAPSA {ECO:0000313|Ensembl:ENSP00000469061};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000469061, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000469061, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000469061}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01103,
CC       ECO:0000256|RuleBase:RU000454, ECO:0000256|SAAS:SAAS01079896}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01103}.
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DR   EMBL; AC008655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M0QXC5; -.
DR   PeptideAtlas; M0QXC5; -.
DR   PRIDE; M0QXC5; -.
DR   Ensembl; ENST00000598915; ENSP00000469061; ENSG00000131400.
DR   UCSC; uc061bpq.1; human.
DR   EuPathDB; HostDB:ENSG00000131400.7; -.
DR   HGNC; HGNC:13395; NAPSA.
DR   OpenTargets; ENSG00000131400; -.
DR   eggNOG; KOG1339; Eukaryota.
DR   eggNOG; ENOG410XNV7; LUCA.
DR   GeneTree; ENSGT00940000160179; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000131400; Expressed in 98 organ(s), highest expression level in upper lobe of lung.
DR   ExpressionAtlas; M0QXC5; baseline and differential.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.70.10; -; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR13683; PTHR13683; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   1: Evidence at protein level;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Proteomics identification {ECO:0000213|MaxQB:M0QXC5,
KW   ECO:0000213|PeptideAtlas:M0QXC5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    268       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004004096.
FT   DOMAIN       78    268       Peptidase A1.
FT                                {ECO:0000259|PROSITE:PS51767}.
FT   NON_TER     268    268       {ECO:0000313|Ensembl:ENSP00000469061}.
SQ   SEQUENCE   268 AA;  29104 MW;  DA54EA8D25AF670B CRC64;
     MSPPPLLQPL LLLLPLLNVE PSGATLIRIP LHRVQPGRRI LNLLRGWREP AELPKLGAPS
     PGDKPIFVPL SNYRDVQYFG EIGLGTPPQN FTVAFDTGSS NLWVPSRRCH FFSVPCSSSS
     FQANGTKFAI QYGTGRVDGI LSEDKLTIGG IKGASVIFGE ALWEPSLVFA FAHFDGILGL
     GFPILSVEGV RPPMDVLVEQ GLLDKPVFSF YLNRDPEEPD GGELVLGGSD PAHYIPPLTF
     VPVTVPAYWQ IHMERVKVGP GLTLCAKG
//