ID   K9N163_HUMAN            Unreviewed;       331 AA.
AC   K9N163;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   12-SEP-2018, entry version 42.
DE   SubName: Full=Interleukin 15 receptor alpha isoform IC2 {ECO:0000313|EMBL:AFY11388.1};
DE   SubName: Full=Interleukin-15 receptor subunit alpha {ECO:0000313|Ensembl:ENSP00000479839};
GN   Name=IL15RA {ECO:0000313|Ensembl:ENSP00000479839};
GN   Synonyms=il15ra {ECO:0000313|EMBL:AFY11388.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AFY11388.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000479839, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|EMBL:AFY11388.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23074221; DOI=10.1074/jbc.M112.378612;
RA   Muller J.R., Waldmann T.A., Kruhlak M.J., Dubois S.;
RT   "Paracrine and Transpresentation Functions of IL-15 Are Mediated by
RT   Diverse Splice Versions of IL-15R? in Human Monocytes and Dendritic
RT   Cells.";
RL   J. Biol. Chem. 287:40328-40338(2012).
RN   [3] {ECO:0000313|EMBL:AFY11388.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mueller J., Waldmann T.A., Kruhlak M.J., Dubois S.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSP00000479839}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; AL137186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JX987305; AFY11388.1; -; mRNA.
DR   UniGene; Hs.445124; -.
DR   PeptideAtlas; K9N163; -.
DR   PRIDE; K9N163; -.
DR   Ensembl; ENST00000620345; ENSP00000479839; ENSG00000134470.
DR   UCSC; uc057rlm.1; human.
DR   EuPathDB; HostDB:ENSG00000134470.19; -.
DR   HGNC; HGNC:5978; IL15RA.
DR   OpenTargets; ENSG00000134470; -.
DR   eggNOG; ENOG410IWP4; Eukaryota.
DR   eggNOG; ENOG410Z8MM; LUCA.
DR   GeneTree; ENSGT00390000000121; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000134470; Expressed in 158 organ(s), highest expression level in ectocervix.
DR   ExpressionAtlas; K9N163; baseline and differential.
DR   CDD; cd00033; CCP; 1.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   SMART; SM00032; CCP; 1.
DR   SUPFAM; SSF57535; SSF57535; 1.
DR   PROSITE; PS50923; SUSHI; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00887447};
KW   Proteomics identification {ECO:0000213|MaxQB:K9N163,
KW   ECO:0000213|PeptideAtlas:K9N163};
KW   Receptor {ECO:0000313|EMBL:AFY11388.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    331       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014101198.
FT   DOMAIN       82    146       Sushi. {ECO:0000259|PROSITE:PS50923}.
SQ   SEQUENCE   331 AA;  35433 MW;  8470D34985E8A88C CRC64;
     MAPRRARGCR TLGLPALLLL LLLRPPATRD ARDRLAVLAG RSRISESFNH EVQTHEACVR
     LRTMENCPQC HHHRTSRQQA GITCPPPMSV EHADIWVKSY SLYSRERYIC NSGFKRKAGT
     SSLTECVLNK ATNVAHWTTP SLKCIRDPAL VHQRPAPPST VTTAGVTPQP ESLSPSGKEP
     AASSPSSNNT AATTAAIVPG SQLMPSKSPS TGTTEISSHE SSHGTPSQTT AKNWELTASA
     SHQPPGVYPQ GHSDTTVAIS TSTVLLCGLS AVSLLACYLK SRWLAKRSLP GDAEAPNMSR
     GGRNAWEQLS RAPATSLLRT PVESALSASR P
//