ID   K9J956_HUMAN            Unreviewed;       154 AA.
AC   K9J956;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   16-JAN-2019, entry version 35.
DE   SubName: Full=CRH receptor 1 variant B {ECO:0000313|EMBL:ACO54880.1};
DE   SubName: Full=Corticotropin-releasing factor receptor 1 {ECO:0000313|Ensembl:ENSP00000478252};
GN   Name=CRHR1 {ECO:0000313|Ensembl:ENSP00000478252};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACO54880.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000478252, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|EMBL:ACO54880.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:ACO54880.1};
RA   Cheng H., Feng Y.-H.;
RT   "Identification of a naturally occurring corticotropin-releasing
RT   hormone receptor 1 variant.";
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000484545}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSP00000478252}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC217771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC243621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FJ200483; ACO54880.1; -; mRNA.
DR   RefSeq; NP_001289947.1; NM_001303018.1.
DR   UniGene; Hs.417628; -.
DR   PRIDE; K9J956; -.
DR   Ensembl; ENST00000618144; ENSP00000478252; ENSG00000276191.
DR   Ensembl; ENST00000619154; ENSP00000484545; ENSG00000120088.
DR   GeneID; 1394; -.
DR   UCSC; uc060giy.1; human.
DR   CTD; 1394; -.
DR   EuPathDB; HostDB:ENSG00000120088.14; -.
DR   HGNC; HGNC:2357; CRHR1.
DR   OpenTargets; ENSG00000120088; -.
DR   GeneTree; ENSGT00940000158410; -.
DR   OrthoDB; 1163977at2759; -.
DR   ChiTaRS; CRHR1; human.
DR   GenomeRNAi; 1394; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000120088; Expressed in 63 organ(s), highest expression level in pituitary gland.
DR   ExpressionAtlas; K9J956; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   InterPro; IPR003052; GPCR_2_CRF1_rcpt.
DR   PRINTS; PR01280; CRFRECEPTOR1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Receptor {ECO:0000313|EMBL:ACO54880.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    154       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014101180.
SQ   SEQUENCE   154 AA;  16708 MW;  9A7535D093B61EF3 CRC64;
     MGGHPQLRLV KALLLLGLNP VSASLQDQHC ESLSLASNIS EKKQGALPCR SHHQLPGPLY
     LPGGPPGGLC PLSAAQEHPV PAKHHPLEPH LRLHPAQRHL VRGPANHEPR GPPEQRGLVQ
     VGDSRLQLLP CDQLLLDVRR GLLPAHSHRA HLLH
//