ID   K7RE46_HUMAN            Unreviewed;       273 AA.
AC   K7RE46;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   16-JAN-2019, entry version 28.
DE   SubName: Full=KIR2DL4 {ECO:0000313|EMBL:AFV74755.1};
DE   SubName: Full=Killer cell immunoglobulin-like receptor 2DL4 {ECO:0000313|Ensembl:ENSP00000478144};
GN   Name=KIR2DL4 {ECO:0000313|EMBL:AFV74755.1,
GN   ECO:0000313|Ensembl:ENSP00000478144};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AFV74755.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000478144, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|EMBL:AFV74755.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Pyo C.-W., Wang R., Vu Q.C., Geraghty D.E.;
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AFV74755.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23394822; DOI=10.1186/1471-2164-14-89;
RA   Pyo C.W., Wang R., Vu Q., Cereb N., Yang S.Y., Duh F.M., Wolinsky S.,
RA   Martin M.P., Carrington M., Geraghty D.E.;
RT   "Recombinant structures expand and contract inter and intragenic
RT   diversification at the KIR locus.";
RL   BMC Genomics 14:89-89(2013).
RN   [4] {ECO:0000313|Ensembl:ENSP00000478144}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
RN   [5] {ECO:0000313|Ensembl:ENSP00000490989}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2017) to UniProtKB.
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DR   EMBL; GU182345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU182348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU182357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KP420438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KP420445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KU645195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JX008028; AFV74755.1; -; Genomic_DNA.
DR   UniGene; Hs.661219; -.
DR   UniGene; Hs.743945; -.
DR   jPOST; K7RE46; -.
DR   PeptideAtlas; K7RE46; -.
DR   Ensembl; ENST00000610911; ENSP00000480840; ENSG00000274945.
DR   Ensembl; ENST00000612865; ENSP00000483940; ENSG00000274189.
DR   Ensembl; ENST00000621031; ENSP00000478144; ENSG00000278606.
DR   Ensembl; ENST00000638388; ENSP00000491611; ENSG00000283869.
DR   Ensembl; ENST00000640596; ENSP00000492668; ENSG00000284460.
DR   Ensembl; ENST00000640883; ENSP00000490989; ENSG00000284509.
DR   UCSC; uc061ess.1; human.
DR   HGNC; HGNC:6332; KIR2DL4.
DR   eggNOG; ENOG410JB08; Eukaryota.
DR   eggNOG; ENOG411179U; LUCA.
DR   Proteomes; UP000005640; Chromosome 19.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 2.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:K7RE46,
KW   ECO:0000213|PeptideAtlas:K7RE46};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    273       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014101170.
FT   TRANSMEM    244    262       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       36    120       IG. {ECO:0000259|SMART:SM00409}.
FT   DOMAIN      131    218       IG. {ECO:0000259|SMART:SM00409}.
SQ   SEQUENCE   273 AA;  30197 MW;  8178B44EC67AD761 CRC64;
     MSMSPTVIIL ACLGFFLDQS VWAHVGGQDK PFCSAWPSAV VPQGGHVTLR CHCRRGFNIF
     TLYKKDGVPV PELYNRIFWN SFLISPVTPA HAGTYRCRGF HPHSPTEWSA PSNPLVIMVT
     GLYEKPSLTA RPGPTVRAGE NVTLSCSSQS SFDIYHLSRE GEAHELRLPA VPSINGTFQA
     DFPLGPATHG ETYRCFGSFH GSPYEWSDPS DPLPVSVTGN PSSSWPSPTE PSFKTGIARH
     LHAVIRYSVA IILFTILPFF LLHRWCSKKK MLL
//