ID   K7ESN3_HUMAN            Unreviewed;       479 AA.
AC   K7ESN3;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 34.
DE   SubName: Full=GH3 domain-containing protein {ECO:0000313|Ensembl:ENSP00000468790};
GN   Name=GHDC {ECO:0000313|Ensembl:ENSP00000468790};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000468790, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000468790, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000468790}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC099811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7ESN3; -.
DR   jPOST; K7ESN3; -.
DR   MaxQB; K7ESN3; -.
DR   PeptideAtlas; K7ESN3; -.
DR   PRIDE; K7ESN3; -.
DR   Ensembl; ENST00000593209; ENSP00000468790; ENSG00000167925.
DR   UCSC; uc060fhk.1; human.
DR   EuPathDB; HostDB:ENSG00000167925.15; -.
DR   HGNC; HGNC:24438; GHDC.
DR   OpenTargets; ENSG00000167925; -.
DR   eggNOG; ENOG410IHE6; Eukaryota.
DR   eggNOG; ENOG410XQH0; LUCA.
DR   GeneTree; ENSGT00390000016401; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000167925; Expressed in 162 organ(s), highest expression level in right adrenal gland.
DR   ExpressionAtlas; K7ESN3; baseline and differential.
DR   InterPro; IPR004993; GH3.
DR   PANTHER; PTHR31901; PTHR31901; 1.
DR   Pfam; PF03321; GH3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:K7ESN3,
KW   ECO:0000213|MaxQB:K7ESN3, ECO:0000213|PeptideAtlas:K7ESN3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    479       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900882.
SQ   SEQUENCE   479 AA;  51814 MW;  E97E4013EA93AACD CRC64;
     MLLWPLLLLL LLLPTLALLR QQRSQDARLS WLAGLQHRVA WGALVWAATW QRRRLEQSTL
     HVHQSQQQAL RWCLQGAQRP HCSLRRSTDI STFRNHLPLT KASQTQQEDS GEQPLPPTSN
     QDLGEASLQA TLLGLAALNK AYPEVLAQGR TARVTLTSPW PRPLPWPGNT LGQVGTPGTK
     DPRALLLDAL RSPGLRALEA GTAVELLDVF LGLETDGEEL AGAIAAGNPG APLRERAAEL
     REALEQGPRG LALRLWPKLQ VVVTLDAGGQ AEAVAALGAL WCQGLAFFSP AYAASGGVLG
     LNLQPEQPHG LYLLPPGAPF IELLPVKEGT QEEAASTLLL AEAQQGKEYE LVLTDRASLT
     RCRLGDVVRV VGAYNQCPVV RFICRLDQTL SVRGEDIGED LFSEALGRAV GQWAGAKLLD
     HGCVESSILD SSAGSAPHYE VFVALRGLRN LSEENRDKIL ASGSALGKRE WTPAQPFPH
//