ID   K7ES70_HUMAN            Unreviewed;       280 AA.
AC   K7ES70;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=Microfibril-associated glycoprotein 4 {ECO:0000313|Ensembl:ENSP00000468578};
GN   Name=MFAP4 {ECO:0000313|Ensembl:ENSP00000468578};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000468578, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000468578, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000468578}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC124066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7ES70; -.
DR   jPOST; K7ES70; -.
DR   PRIDE; K7ES70; -.
DR   Ensembl; ENST00000497081; ENSP00000468578; ENSG00000166482.
DR   UCSC; uc060cla.1; human.
DR   EuPathDB; HostDB:ENSG00000166482.11; -.
DR   HGNC; HGNC:7035; MFAP4.
DR   OpenTargets; ENSG00000166482; -.
DR   eggNOG; KOG2579; Eukaryota.
DR   eggNOG; ENOG410ZYS4; LUCA.
DR   GeneTree; ENSGT00940000154615; -.
DR   OMA; QGYQTDG; -.
DR   ChiTaRS; MFAP4; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000166482; Expressed in 183 organ(s), highest expression level in thoracic aorta.
DR   ExpressionAtlas; K7ES70; baseline and differential.
DR   CDD; cd00087; FReD; 1.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:K7ES70,
KW   ECO:0000213|MaxQB:K7ES70, ECO:0000213|PeptideAtlas:K7ES70};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     45       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        46    280       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900850.
FT   DOMAIN       57    280       Fibrinogen C-terminal.
FT                                {ECO:0000259|PROSITE:PS51406}.
SQ   SEQUENCE   280 AA;  31326 MW;  9C5F55A24E0244D5 CRC64;
     MVGANAKRTG DLWSWEGAVL TLSAHRQALL ALPLLLLLST PPCAPQVSGI RGDALERFCL
     QQPLDCDDIY AQGYQSDGVY LIYPSGPSVP VPVFCDMTTE GGKWTVFQKR FNGSVSFFRG
     WNDYKLGFGR ADGEYWLGLQ NMHLLTLKQK YELRVDLEDF ENNTAYAKYA DFSISPNAVS
     AEEDGYTLFV AGFEDGGAGD SLSYHSGQKF STFDRDQDLF VQNCAALSSG AFWFRSCHFA
     NLNGFYLGGS HLSYANGINW AQWKGFYYSL KRTEMKIRRA
//