ID   K7ERG9_HUMAN            Unreviewed;       260 AA.
AC   K7ERG9;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   SubName: Full=Complement factor D {ECO:0000313|Ensembl:ENSP00000468253};
GN   Name=CFD {ECO:0000313|Ensembl:ENSP00000468253};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000468253, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000468253, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000213|PubMed:22905912}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22905912; DOI=10.1021/pr300539b;
RA   Rosenow A., Noben J.P., Jocken J., Kallendrusch S.,
RA   Fischer-Posovszky P., Mariman E.C., Renes J.;
RT   "Resveratrol-induced changes of the human adipocyte secretion
RT   profile.";
RL   J. Proteome Res. 11:4733-4743(2012).
RN   [3] {ECO:0000313|Ensembl:ENSP00000468253}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSP00000488580}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
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DR   EMBL; AC112706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC212840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001304264.1; NM_001317335.1.
DR   UniGene; Hs.155597; -.
DR   jPOST; K7ERG9; -.
DR   PRIDE; K7ERG9; -.
DR   Ensembl; ENST00000592860; ENSP00000468253; ENSG00000197766.
DR   Ensembl; ENST00000632706; ENSP00000488580; ENSG00000274619.
DR   GeneID; 1675; -.
DR   UCSC; uc060qro.1; human.
DR   CTD; 1675; -.
DR   EuPathDB; HostDB:ENSG00000197766.7; -.
DR   HGNC; HGNC:2771; CFD.
DR   OpenTargets; ENSG00000197766; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000162255; -.
DR   OMA; NGGKKCG; -.
DR   OrthoDB; 1314811at2759; -.
DR   ChiTaRS; CFD; human.
DR   GenomeRNAi; 1675; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000197766; Expressed in 194 organ(s), highest expression level in adipose tissue of abdominal region.
DR   ExpressionAtlas; K7ERG9; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006957; P:complement activation, alternative pathway; IEA:InterPro.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR037561; Complement_factor_D.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR43890:SF17; PTHR43890:SF17; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Proteomics identification {ECO:0000213|MaxQB:K7ERG9,
KW   ECO:0000213|PeptideAtlas:K7ERG9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    260       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014099472.
FT   DOMAIN       33    260       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
SQ   SEQUENCE   260 AA;  27863 MW;  271B5A14D64E0990 CRC64;
     MHSWERLAVL VLLGAAACGE EAWAWAAPPR GRILGGREAE AHARPYMASV QLNGAHLCGG
     VLVAEQWVLS AAHCLEDAAD GKVQVLLGAH SLSQPEPSKR LYDVLRAVPH PDSQPDTIDH
     DLLLLQLSEK ATLGPAVRPL PWQRVDRDVA PGTLCDVAGW GIVNHAGRRP DSLQHVLLPV
     LDRATCNRRT HHDGAITERL MCAESNRRDS CKGDSGGPLV CGGVLEGVVT SGSRVCGNRK
     KPGIYTRVAS YAAWIDSVLA
//