ID   K7ERC8_HUMAN            Unreviewed;       298 AA.
AC   K7ERC8;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   13-FEB-2019, entry version 48.
DE   SubName: Full=3-ketodihydrosphingosine reductase {ECO:0000313|Ensembl:ENSP00000468203};
GN   Name=KDSR {ECO:0000313|Ensembl:ENSP00000468203};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000468203, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000468203, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000468203}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family. {ECO:0000256|RuleBase:RU000363}.
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DR   EMBL; AC021803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC036176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005266734.1; XM_005266677.2.
DR   UniGene; Hs.74050; -.
DR   ProteinModelPortal; K7ERC8; -.
DR   EPD; K7ERC8; -.
DR   jPOST; K7ERC8; -.
DR   PeptideAtlas; K7ERC8; -.
DR   PRIDE; K7ERC8; -.
DR   Ensembl; ENST00000591902; ENSP00000468203; ENSG00000119537.
DR   GeneID; 2531; -.
DR   UCSC; uc060puw.1; human.
DR   CTD; 2531; -.
DR   EuPathDB; HostDB:ENSG00000119537.15; -.
DR   HGNC; HGNC:4021; KDSR.
DR   OpenTargets; ENSG00000119537; -.
DR   GeneTree; ENSGT00940000156961; -.
DR   ChiTaRS; KDSR; human.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000119537; Expressed in 231 organ(s), highest expression level in endothelial cell.
DR   ExpressionAtlas; K7ERC8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:K7ERC8,
KW   ECO:0000213|MaxQB:K7ERC8, ECO:0000213|PeptideAtlas:K7ERC8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    298       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015334661.
FT   TRANSMEM    258    281       Helical. {ECO:0000256|SAM:Phobius}.
FT   COILED       91    111       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   298 AA;  32726 MW;  A1278207646C7AE6 CRC64;
     MLLLAAAFLV AFVLLLYMVS PLISPKPLAL PGAHVVVTGG SSGIGKCIAI ECYKQGAFIT
     LVARNEDKLL QAKKEIEMHS INDKQVVLCI SVDVSQDYNQ VENVIKQAQE KLGPVDMLVN
     CAGMAVSGKF EDLEVSTFER LMSINYLGSV YPSRAVITTM KERRVGRIVF VSSQAGQLGL
     FGFTAYSASK FAIRGLAEAL QMEVKPYNVY ITVAYPPDTD TPGFAEENRT KPLETRLISE
     TTSVCKPEQV AKQIVKDAIV VTMGLFRTIA LFYLGSFDSI VRRCMMQREK SENADKTA
//