ID   K7ERB5_HUMAN            Unreviewed;       276 AA.
AC   K7ERB5;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Erythropoietin receptor {ECO:0000313|Ensembl:ENSP00000468187};
GN   Name=EPOR {ECO:0000313|Ensembl:ENSP00000468187};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000468187, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000468187, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000468187}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC024575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7ERB5; -.
DR   jPOST; K7ERB5; -.
DR   PRIDE; K7ERB5; -.
DR   Ensembl; ENST00000591958; ENSP00000468187; ENSG00000187266.
DR   UCSC; uc060trv.1; human.
DR   EuPathDB; HostDB:ENSG00000187266.13; -.
DR   HGNC; HGNC:3416; EPOR.
DR   OpenTargets; ENSG00000187266; -.
DR   GeneTree; ENSGT00940000160315; -.
DR   ChiTaRS; EPOR; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000187266; Expressed in 226 organ(s), highest expression level in type B pancreatic cell.
DR   ExpressionAtlas; K7ERB5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR009167; Erythropoietin_rcpt.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR23037:SF28; PTHR23037:SF28; 1.
DR   Pfam; PF09067; EpoR_lig-bind; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    276       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900913.
FT   DOMAIN       75    175       EpoR_lig-bind.
FT                                {ECO:0000259|Pfam:PF09067}.
SQ   SEQUENCE   276 AA;  29864 MW;  EB25A83B80C4A733 CRC64;
     MDHLGASLWP QVGSLCLLLA GAAWAPPPNL PDPKFESKGW GGAGSPELEV LNAAPSSAGR
     WVGRCAPVVT AGDTALLAAR GPEELLCFTE RLEDLVCFWE EAASAGVGPG NYSFSYQLED
     EPWKLCRLHQ APTARGAVRF WCSLPTADTS SFVPLELRVT AASGAPRYHR VIHINEVVLL
     DAPVGLVARL ADESGHVVLR WLPPPETPMT SHIRYEVDVS AGNGAGSVQR GTVFLSPDWL
     SSTRARPHVI YFCLLRVPRP DSAPRWRSWR AAPSVC
//