ID   K7ER74_HUMAN            Unreviewed;       178 AA.
AC   K7ER74;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   13-FEB-2019, entry version 40.
DE   SubName: Full=APOC4-APOC2 readthrough (NMD candidate) {ECO:0000313|Ensembl:ENSP00000468139};
GN   Name=APOC4-APOC2 {ECO:0000313|Ensembl:ENSP00000468139};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000468139, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000468139, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000468139}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC011481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7ER74; -.
DR   SMR; K7ER74; -.
DR   BioMuta; APOC4-APOC2; -.
DR   jPOST; K7ER74; -.
DR   PeptideAtlas; K7ER74; -.
DR   PRIDE; K7ER74; -.
DR   Ensembl; ENST00000589057; ENSP00000468139; ENSG00000224916.
DR   UCSC; uc060zus.1; human.
DR   EuPathDB; HostDB:ENSG00000224916.8; -.
DR   GeneCards; APOC4-APOC2; -.
DR   HGNC; HGNC:44426; APOC4-APOC2.
DR   OpenTargets; ENSG00000224916; -.
DR   eggNOG; ENOG410J3QQ; Eukaryota.
DR   eggNOG; ENOG4111AXD; LUCA.
DR   GeneTree; ENSGT00390000015914; -.
DR   OMA; ACTAVHQ; -.
DR   ChiTaRS; APOC4-APOC2; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000224916; Expressed in 80 organ(s), highest expression level in right lobe of liver.
DR   GO; GO:0042627; C:chylomicron; IEA:InterPro.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR   Gene3D; 1.10.1440.10; -; 1.
DR   InterPro; IPR008019; Apo-CII.
DR   InterPro; IPR023121; ApoC-II_dom_sf.
DR   InterPro; IPR028120; APOC4.
DR   PANTHER; PTHR16566; PTHR16566; 1.
DR   Pfam; PF05355; Apo-CII; 1.
DR   Pfam; PF15119; APOC4; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    178       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900911.
SQ   SEQUENCE   178 AA;  20049 MW;  F8EA96DEC7C424DC CRC64;
     MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV RGRMKELLET
     VVNRTRDGWQ WFWSLDTMGT RLLPALFLVL LVLGFEVQGT QQPQQDEMPS PTFLTQVKES
     LSSYWESAKT AAQNLYEKTY LPAVDEKLRD LYSKSTAAMS TYTGIFTDQV LSVLKGEE
//