ID   K7EQS7_HUMAN            Unreviewed;       155 AA.
AC   K7EQS7;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=3-ketodihydrosphingosine reductase {ECO:0000313|Ensembl:ENSP00000467962};
DE   Flags: Fragment;
GN   Name=KDSR {ECO:0000313|Ensembl:ENSP00000467962};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467962, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000467962, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000467962}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC021803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC036176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EQS7; -.
DR   jPOST; K7EQS7; -.
DR   MaxQB; K7EQS7; -.
DR   PeptideAtlas; K7EQS7; -.
DR   PRIDE; K7EQS7; -.
DR   Ensembl; ENST00000592327; ENSP00000467962; ENSG00000119537.
DR   UCSC; uc060pva.1; human.
DR   EuPathDB; HostDB:ENSG00000119537.15; -.
DR   HGNC; HGNC:4021; KDSR.
DR   OpenTargets; ENSG00000119537; -.
DR   eggNOG; KOG1210; Eukaryota.
DR   eggNOG; ENOG410YF8M; LUCA.
DR   GeneTree; ENSGT00940000156961; -.
DR   ChiTaRS; KDSR; human.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000119537; Expressed in 231 organ(s), highest expression level in endothelial cell.
DR   ExpressionAtlas; K7EQS7; baseline and differential.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:K7EQS7,
KW   ECO:0000213|MaxQB:K7EQS7, ECO:0000213|PeptideAtlas:K7EQS7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    155       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900847.
FT   COILED       91    111       {ECO:0000256|SAM:Coils}.
FT   NON_TER     155    155       {ECO:0000313|Ensembl:ENSP00000467962}.
SQ   SEQUENCE   155 AA;  16773 MW;  EA84F262CF9FFDAA CRC64;
     MLLLAAAFLV AFVLLLYMVS PLISPKPLAL PGAHVVVTGG SSGIGKCIAI ECYKQGAFIT
     LVARNEDKLL QAKKEIEMHS INDKQVVLCI SVDVSQDYNQ VENVIKQAQE KLGPVDMLVN
     CAGMAVSGKF EDLERLMSIN YLGSVYPSRA VITTM
//