ID   K7EPL0_HUMAN            Unreviewed;       191 AA.
AC   K7EPL0;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 31.
DE   SubName: Full=Granulins {ECO:0000313|Ensembl:ENSP00000467431};
DE   Flags: Fragment;
GN   Name=GRN {ECO:0000313|Ensembl:ENSP00000467431};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467431, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000467431, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000467431}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC003043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EPL0; -.
DR   SMR; K7EPL0; -.
DR   jPOST; K7EPL0; -.
DR   MaxQB; K7EPL0; -.
DR   PeptideAtlas; K7EPL0; -.
DR   PRIDE; K7EPL0; -.
DR   Ensembl; ENST00000587387; ENSP00000467431; ENSG00000030582.
DR   UCSC; uc060fzu.1; human.
DR   EuPathDB; HostDB:ENSG00000030582.16; -.
DR   HGNC; HGNC:4601; GRN.
DR   OpenTargets; ENSG00000030582; -.
DR   GeneTree; ENSGT00470000042293; -.
DR   ChiTaRS; GRN; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000030582; Expressed in 235 organ(s), highest expression level in esophagus mucosa.
DR   ExpressionAtlas; K7EPL0; baseline and differential.
DR   Gene3D; 3.10.20.500; -; 2.
DR   InterPro; IPR000118; Granulin.
DR   InterPro; IPR039036; Granulin_fam.
DR   InterPro; IPR037277; Granulin_sf.
DR   PANTHER; PTHR12274; PTHR12274; 1.
DR   Pfam; PF00396; Granulin; 2.
DR   SMART; SM00277; GRAN; 2.
DR   PROSITE; PS00799; GRANULINS; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:K7EPL0,
KW   ECO:0000213|MaxQB:K7EPL0, ECO:0000213|PeptideAtlas:K7EPL0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    191       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900818.
FT   DOMAIN      106    119       GRANULINS. {ECO:0000259|PROSITE:PS00799}.
FT   DOMAIN      172    185       GRANULINS. {ECO:0000259|PROSITE:PS00799}.
FT   NON_TER     191    191       {ECO:0000313|Ensembl:ENSP00000467431}.
SQ   SEQUENCE   191 AA;  20253 MW;  9B5E9A34D747465E CRC64;
     MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP
     CQVDAHCSAG HSCIFTVSGT SSCCPFPEIK GPCQCRFLCV PQAVACGDGH HCCPRGFHCS
     ADGRSCFQRS GNNSVGAIQC PDSQFECPDF STCCVMVDGS WGCCPMPQAS CCEDRVHCCP
     HGAFCDLVHT R
//