ID   K7EPJ4_HUMAN            Unreviewed;      1162 AA.
AC   K7EPJ4;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Cartilage intermediate layer protein 2, isoform CRA_b {ECO:0000313|EMBL:EAW84833.1};
GN   Name=CILP2 {ECO:0000313|EMBL:EAW84833.1,
GN   ECO:0000313|Ensembl:ENSP00000467413};
GN   ORFNames=hCG_38566 {ECO:0000313|EMBL:EAW84833.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467413, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|EMBL:EAW84833.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11181995; DOI=10.1126/science.1058040;
RA   Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA   Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA   Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA   Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA   Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA   Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA   Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA   Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA   Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA   Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA   Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA   Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA   Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA   Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA   Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA   Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA   Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA   Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA   Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA   Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA   Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA   Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA   Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA   Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA   Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA   Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA   Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA   McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA   Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA   Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA   Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA   Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA   Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA   Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA   Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA   Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA   Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA   Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA   Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA   Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA   Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA   Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA   Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA   McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA   Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA   Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA   Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT   "The sequence of the human genome.";
RL   Science 291:1304-1351(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000467413, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3] {ECO:0000313|EMBL:EAW84833.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSP00000467413}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC011448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471106; EAW84833.1; -; Genomic_DNA.
DR   UniGene; Hs.279574; -.
DR   EPD; K7EPJ4; -.
DR   jPOST; K7EPJ4; -.
DR   PRIDE; K7EPJ4; -.
DR   Ensembl; ENST00000586018; ENSP00000467413; ENSG00000160161.
DR   UCSC; uc002nmw.5; human.
DR   EuPathDB; HostDB:ENSG00000160161.9; -.
DR   HGNC; HGNC:24213; CILP2.
DR   OpenTargets; ENSG00000160161; -.
DR   eggNOG; ENOG410IJBD; Eukaryota.
DR   eggNOG; ENOG410XXZR; LUCA.
DR   GeneTree; ENSGT00390000008152; -.
DR   OMA; GVWEEES; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000160161; Expressed in 84 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; K7EPJ4; baseline and differential.
DR   Gene3D; 2.20.100.10; -; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR039675; CILP1/CILP2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR025155; WxxW_domain.
DR   PANTHER; PTHR15031; PTHR15031; 1.
DR   Pfam; PF13330; Mucin2_WxxW; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF49464; SSF49464; 1.
DR   SUPFAM; SSF82895; SSF82895; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:K7EPJ4,
KW   ECO:0000213|PeptideAtlas:K7EPJ4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1162       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014099512.
FT   DOMAIN      298    382       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   1162 AA;  126857 MW;  4F6B29E6CA058089 CRC64;
     MASLLPLLCL CVVAAHLAGA RDATPTEEPM ATALGLERRS VYTGQPSPAL EDWEARAVPA
     EASEWTSWFN VDHPGGDGDF ESLAAIRFYY GPARVCPRPL ALEARTTDWA LPSAVGERVH
     LNPTRGFWCL NREQPRGRRC SNYHVRFRCP LEASWGAWGP WGPCSGSCGP GRRLRRRHCP
     SPAGDACPGR PLEAQKCVRP RCPGCSLDTC ECPDHILLGS VVTPSGQPLL GARVSLRDQP
     GTVATSDAHG TFRVPGVCAD SRANIRAQMD GFSAGEAQAQ ANGSISVVTI ILDKLEKPYL
     VKHPESRVRE AGQNVTFCCK ASGTPMPKKY SWFHNGTLLD RRAHGYGAHL ELRGLRPDQA
     GIYHCKAWNE AGAVRSGTAR LTVLAPGQPA CDPRPREYLI KLPEDCGQPG SGPAYLDVGL
     CPDTRCPSLA GSSPRCGDAS SRCCSVRRLE RREIHCPGYV LPVKVVAECG CQKCLPPRGL
     VRGRVVAADS GEPLRFARIL LGQEPIGFTA YQGDFTIEVP PSTQRLVVTF VDPSGEFMDA
     VRVLPFDPRG AGVYHEVKAM RKKAPVILHT SQSNTIPLGE LEDEAPLGEL VLPSGAFRRA
     DGKPYSGPVE ARVTFVDPRD LTSAASAPSD LRFVDSDGEL APLRTYGMFS VDLRAPGSAE
     QLQVGPVAVR VAASQIHMPG HVEALKLWSL NPETGLWEEE SGFRREGSSG PRVRREERVF
     LVGNVEIRER RLFNLDVPER RRCFVKVRAY ANDKFTPSEQ VEGVVVTLVN LEPAPGFSAN
     PRAWGRFDSA VTGPNGACLP AFCDADRPDA YTALVTATLG GEELEPAPSL PRPLPATVGV
     TQPYLDRLGY RRTDHDDPAF KRNGFRINLA KPRPGDPAEA NGPVYPWRSL RECQGAPVTA
     SHFRFARVEA DKYEYNVVPF REGTPASWTG DLLAWWPNPQ EFRACFLKVK IQGPQEYMVR
     SHNAGGSHPR TRGQLYGLRD ARSVRDPERP GTSAACVEFK CSGMLFDQRQ VDRTLVTIMP
     QGSCRRVAVN GLLRDYLTRH PPPVPAEDPA AFSMLAPLDP LGHNYGVYTV TDQSPRLAKE
     IAIGRCFDGS SDGFSREMKA DAGTAVTFQC REPPAGRPSL FQRLLESPAT ALGDIRREMS
     EAAQAQARAS GPLRTRRGRV RQ
//