ID   K7EPA3_HUMAN            Unreviewed;       454 AA.
AC   K7EPA3;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   16-JAN-2019, entry version 33.
DE   SubName: Full=Transmembrane protein 161A {ECO:0000313|Ensembl:ENSP00000467300};
GN   Name=TMEM161A {ECO:0000313|Ensembl:ENSP00000467300};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467300, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000467300, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000467300}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
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DR   EMBL; AC002126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016882405.1; XM_017026916.1.
DR   UniGene; Hs.631629; -.
DR   ProteinModelPortal; K7EPA3; -.
DR   EPD; K7EPA3; -.
DR   jPOST; K7EPA3; -.
DR   MaxQB; K7EPA3; -.
DR   PeptideAtlas; K7EPA3; -.
DR   PRIDE; K7EPA3; -.
DR   Ensembl; ENST00000587583; ENSP00000467300; ENSG00000064545.
DR   GeneID; 54929; -.
DR   UCSC; uc060vxe.1; human.
DR   CTD; 54929; -.
DR   EuPathDB; HostDB:ENSG00000064545.14; -.
DR   HGNC; HGNC:26020; TMEM161A.
DR   OpenTargets; ENSG00000064545; -.
DR   GeneTree; ENSGT00390000000672; -.
DR   OrthoDB; 734854at2759; -.
DR   ChiTaRS; TMEM161A; human.
DR   GenomeRNAi; 54929; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000064545; Expressed in 214 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; K7EPA3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR019395; Transmembrane_161A/B.
DR   PANTHER; PTHR13624; PTHR13624; 2.
DR   Pfam; PF10268; Tmemb_161AB; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:K7EPA3,
KW   ECO:0000213|MaxQB:K7EPA3, ECO:0000213|PeptideAtlas:K7EPA3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    454       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003904162.
FT   TRANSMEM    111    132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    144    162       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    200    219       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    240    259       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    291    315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    367       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    425    447       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   454 AA;  50553 MW;  3F9F4CE119012F9F CRC64;
     MAVLGVQLVV TLLTATLMHR LAPHCSFARW LLCNGSLFRY KHPSEEELRA LAGKPRPRGR
     KERWANGLSE EKPLSVPRDA PFQLETCPLT TVDALEAYYY MLGPAKETNI AVFWCLLTVT
     FSIKMFLTVT RLYFSAEEGG ERSVCLTFAF LFLLLAMLVQ VVREETLELG LEPGLASMTQ
     NLEPLLKKQG WDWALPVAKL AIRVGLAVVG SVLGAFLTFP GLRLAQTHRD ALTMSEDRPM
     LQFLLHTSFL SPLFILWLWT KPIARDFLHQ PPFGETRFSL LSDSAFDSGR LWLLVVLCLL
     RLAVTRPHLQ AYLCLAKARV EQLRREAGRI EAREIQQRVV RVYCYVTVVS LQYLTPLILT
     LNCTLLLKTL GGYSWGLGPA PLLSPDPSSA SAAPIGSGED EVQQTAARIA GALGGLLTPL
     FLRGVLAYLI WWTAACQLLA SLFGLYFHQH LAGS
//