ID   K7EP50_HUMAN            Unreviewed;       130 AA.
AC   K7EP50;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   05-DEC-2018, entry version 40.
DE   SubName: Full=Erythropoietin receptor {ECO:0000313|Ensembl:ENSP00000467230};
GN   Name=EPOR {ECO:0000313|Ensembl:ENSP00000467230};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467230, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000467230, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000467230}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC024575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EP50; -.
DR   PRIDE; K7EP50; -.
DR   Ensembl; ENST00000586890; ENSP00000467230; ENSG00000187266.
DR   UCSC; uc060trw.1; human.
DR   EuPathDB; HostDB:ENSG00000187266.13; -.
DR   HGNC; HGNC:3416; EPOR.
DR   OpenTargets; ENSG00000187266; -.
DR   GeneTree; ENSGT00940000160315; -.
DR   ChiTaRS; EPOR; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000187266; Expressed in 226 organ(s), highest expression level in type B pancreatic cell.
DR   ExpressionAtlas; K7EP50; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR009167; Erythropoietin_rcpt.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR23037:SF28; PTHR23037:SF28; 1.
DR   Pfam; PF09067; EpoR_lig-bind; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    130       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900789.
FT   DOMAIN       37     92       EpoR_lig-bind.
FT                                {ECO:0000259|Pfam:PF09067}.
SQ   SEQUENCE   130 AA;  13803 MW;  B2C624DFFE5D2043 CRC64;
     MDHLGASLWP QVGSLCLLLA GAAWAPPPNL PDPKFESKAA LLAARGPEEL LCFTERLEDL
     VCFWEEAASA GVGPGNYSFS YQLDRGHWRE TCGSRAGTPS MGRGANTPAI TAGTRPQTSG
     WDNNASKSRG
//