ID   K7EP40_HUMAN            Unreviewed;       129 AA.
AC   K7EP40;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637};
DE   Flags: Fragment;
GN   Name=CLDN7 {ECO:0000313|Ensembl:ENSP00000467220};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467220, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000467220, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000467220}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- FUNCTION: Plays a major role in tight junction-specific
CC       obliteration of the intercellular space, through calcium-
CC       independent cell-adhesion activity.
CC       {ECO:0000256|RuleBase:RU060637}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00567644}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00567644}.
CC   -!- SIMILARITY: Belongs to the claudin family.
CC       {ECO:0000256|RuleBase:RU060637, ECO:0000256|SAAS:SAAS00567656}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU060637}.
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DR   EMBL; AC003688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EP40; -.
DR   EPD; K7EP40; -.
DR   jPOST; K7EP40; -.
DR   MaxQB; K7EP40; -.
DR   PeptideAtlas; K7EP40; -.
DR   PRIDE; K7EP40; -.
DR   Ensembl; ENST00000571932; ENSP00000467220; ENSG00000181885.
DR   UCSC; uc060alv.1; human.
DR   EuPathDB; HostDB:ENSG00000181885.18; -.
DR   HGNC; HGNC:2049; CLDN7.
DR   OpenTargets; ENSG00000181885; -.
DR   eggNOG; ENOG410IHPN; Eukaryota.
DR   eggNOG; ENOG4111GPP; LUCA.
DR   GeneTree; ENSGT00940000160672; -.
DR   ChiTaRS; CLDN7; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000181885; Expressed in 143 organ(s), highest expression level in mucosa of transverse colon.
DR   ExpressionAtlas; K7EP40; baseline and differential.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-UniRule.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR003552; Claudin7.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01381; CLAUDIN7.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   1: Evidence at protein level;
KW   Cell junction {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455883};
KW   Cell membrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455877};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455877, ECO:0000256|SAAS:SAAS00463381};
KW   Proteomics identification {ECO:0000213|MaxQB:K7EP40,
KW   ECO:0000213|PeptideAtlas:K7EP40};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Tight junction {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455883};
KW   Transmembrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00463381};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00463381}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    129       Claudin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900839.
FT   TRANSMEM     70     96       Helical. {ECO:0000256|RuleBase:RU060637}.
FT   NON_TER     129    129       {ECO:0000313|Ensembl:ENSP00000467220}.
SQ   SEQUENCE   129 AA;  13649 MW;  FEAF5880095EF870 CRC64;
     MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG
     MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM
     GGGIIFIVA
//