ID   K7EP36_HUMAN            Unreviewed;       259 AA.
AC   K7EP36;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   SubName: Full=Galectin-3-binding protein {ECO:0000313|Ensembl:ENSP00000467211};
DE   Flags: Fragment;
GN   Name=LGALS3BP {ECO:0000313|Ensembl:ENSP00000467211};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467211, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000467211, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000467211}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC100788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EP36; -.
DR   jPOST; K7EP36; -.
DR   PeptideAtlas; K7EP36; -.
DR   PRIDE; K7EP36; -.
DR   Ensembl; ENST00000589527; ENSP00000467211; ENSG00000108679.
DR   UCSC; uc060kxj.1; human.
DR   EuPathDB; HostDB:ENSG00000108679.12; -.
DR   HGNC; HGNC:6564; LGALS3BP.
DR   OpenTargets; ENSG00000108679; -.
DR   eggNOG; ENOG410IY2Y; Eukaryota.
DR   eggNOG; ENOG410YBYF; LUCA.
DR   GeneTree; ENSGT00940000162516; -.
DR   ChiTaRS; LGALS3BP; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000108679; Expressed in 221 organ(s), highest expression level in heart left ventricle.
DR   ExpressionAtlas; K7EP36; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   Gene3D; 3.10.250.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF00530; SRCR; 1.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF56487; SSF56487; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00420; SRCR_1; 1.
DR   PROSITE; PS50287; SRCR_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00196,
KW   ECO:0000256|SAAS:SAAS00873970};
KW   Proteomics identification {ECO:0000213|EPD:K7EP36,
KW   ECO:0000213|MaxQB:K7EP36, ECO:0000213|PeptideAtlas:K7EP36};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    259       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003903233.
FT   DOMAIN       24    124       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DOMAIN      153    221       BTB. {ECO:0000259|PROSITE:PS50097}.
FT   DISULFID     49    113       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID     62    123       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID     93    103       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   NON_TER     259    259       {ECO:0000313|Ensembl:ENSP00000467211}.
SQ   SEQUENCE   259 AA;  28287 MW;  68ADC25C9E307EE6 CRC64;
     MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD NLWDLTDASV
     VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL ADCKSLGWLK SNCRHERDAG
     VVCTNETRST HTLDLSRELS EALGQIFDSQ RGCDLSISVN VQGEDALGFC GHTVILTANL
     EAQALWKEPG SNVTMSVDAE CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ
     GYCASLFAIL LPQDPSFQM
//