ID   K7ENN1_HUMAN            Unreviewed;       135 AA.
AC   K7ENN1;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   12-SEP-2018, entry version 31.
DE   SubName: Full=Granulins {ECO:0000313|Ensembl:ENSP00000467022};
DE   Flags: Fragment;
GN   Name=GRN {ECO:0000313|Ensembl:ENSP00000467022};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467022, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000467022, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000467022}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC003043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7ENN1; -.
DR   PeptideAtlas; K7ENN1; -.
DR   Ensembl; ENST00000591740; ENSP00000467022; ENSG00000030582.
DR   UCSC; uc060fzs.1; human.
DR   EuPathDB; HostDB:ENSG00000030582.16; -.
DR   HGNC; HGNC:4601; GRN.
DR   OpenTargets; ENSG00000030582; -.
DR   eggNOG; KOG4296; Eukaryota.
DR   eggNOG; ENOG410XR6S; LUCA.
DR   GeneTree; ENSGT00470000042293; -.
DR   ChiTaRS; GRN; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000030582; Expressed in 235 organ(s), highest expression level in esophagus mucosa.
DR   ExpressionAtlas; K7ENN1; baseline and differential.
DR   Gene3D; 3.10.20.500; -; 1.
DR   InterPro; IPR000118; Granulin.
DR   InterPro; IPR039036; Granulin_fam.
DR   InterPro; IPR037277; Granulin_sf.
DR   PANTHER; PTHR12274; PTHR12274; 1.
DR   Pfam; PF00396; Granulin; 1.
DR   SMART; SM00277; GRAN; 1.
DR   PROSITE; PS00799; GRANULINS; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:K7ENN1,
KW   ECO:0000213|PeptideAtlas:K7ENN1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    135       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900798.
FT   DOMAIN       92    105       GRANULINS. {ECO:0000259|PROSITE:PS00799}.
FT   NON_TER     135    135       {ECO:0000313|Ensembl:ENSP00000467022}.
SQ   SEQUENCE   135 AA;  14104 MW;  3EF8EC2638F24CD9 CRC64;
     MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP
     CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR SCFQRSGNNS
     VGAIQCPDSQ FECPD
//