ID   K7ENI2_HUMAN            Unreviewed;       111 AA.
AC   K7ENI2;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   12-SEP-2018, entry version 31.
DE   SubName: Full=Granulins {ECO:0000313|Ensembl:ENSP00000466956};
DE   Flags: Fragment;
GN   Name=GRN {ECO:0000313|Ensembl:ENSP00000466956};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466956, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000466956, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000466956}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC003043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7ENI2; -.
DR   PeptideAtlas; K7ENI2; -.
DR   Ensembl; ENST00000589536; ENSP00000466956; ENSG00000030582.
DR   UCSC; uc060fzl.1; human.
DR   EuPathDB; HostDB:ENSG00000030582.16; -.
DR   HGNC; HGNC:4601; GRN.
DR   OpenTargets; ENSG00000030582; -.
DR   eggNOG; KOG4296; Eukaryota.
DR   eggNOG; ENOG410XR6S; LUCA.
DR   GeneTree; ENSGT00470000042293; -.
DR   ChiTaRS; GRN; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000030582; Expressed in 235 organ(s), highest expression level in esophagus mucosa.
DR   ExpressionAtlas; K7ENI2; baseline and differential.
DR   Gene3D; 3.10.20.500; -; 1.
DR   InterPro; IPR000118; Granulin.
DR   InterPro; IPR039036; Granulin_fam.
DR   InterPro; IPR037277; Granulin_sf.
DR   PANTHER; PTHR12274; PTHR12274; 1.
DR   Pfam; PF00396; Granulin; 1.
DR   SMART; SM00277; GRAN; 1.
DR   PROSITE; PS00799; GRANULINS; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:K7ENI2,
KW   ECO:0000213|PeptideAtlas:K7ENI2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    111       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003904152.
FT   DOMAIN       92    105       GRANULINS. {ECO:0000259|PROSITE:PS00799}.
FT   NON_TER     111    111       {ECO:0000313|Ensembl:ENSP00000466956}.
SQ   SEQUENCE   111 AA;  11519 MW;  788D18AA7CD62125 CRC64;
     MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP
     CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR S
//