ID   K7ENE5_HUMAN            Unreviewed;       218 AA.
AC   K7ENE5;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 33.
DE   SubName: Full=Deoxyribonuclease-2-alpha {ECO:0000313|Ensembl:ENSP00000466912};
DE   Flags: Fragment;
GN   Name=DNASE2 {ECO:0000313|Ensembl:ENSP00000466912};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466912, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000466912, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000466912}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC020934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; K7ENE5; -.
DR   jPOST; K7ENE5; -.
DR   MaxQB; K7ENE5; -.
DR   PeptideAtlas; K7ENE5; -.
DR   PRIDE; K7ENE5; -.
DR   Ensembl; ENST00000592506; ENSP00000466912; ENSG00000105612.
DR   UCSC; uc060ueq.1; human.
DR   EuPathDB; HostDB:ENSG00000105612.8; -.
DR   HGNC; HGNC:2960; DNASE2.
DR   OpenTargets; ENSG00000105612; -.
DR   GeneTree; ENSGT00390000002634; -.
DR   ChiTaRS; DNASE2; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000105612; Expressed in 213 organ(s), highest expression level in pituitary gland.
DR   ExpressionAtlas; K7ENE5; baseline and differential.
DR   GO; GO:0004531; F:deoxyribonuclease II activity; IEA:InterPro.
DR   InterPro; IPR004947; DNase_II.
DR   PANTHER; PTHR10858; PTHR10858; 2.
DR   Pfam; PF03265; DNase_II; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:K7ENE5,
KW   ECO:0000213|MaxQB:K7ENE5, ECO:0000213|PeptideAtlas:K7ENE5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    218       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900794.
FT   NON_TER     218    218       {ECO:0000313|Ensembl:ENSP00000466912}.
SQ   SEQUENCE   218 AA;  24085 MW;  755CA15FBF8AC6A8 CRC64;
     MIPLLLAALL CVPAGALTCY GDSGQPVDWF VVYKLPALRG SGEAAQRGLQ YKYLDESSGG
     WRDGRALINS PEGAVGRSLQ PLYRSNTSQL AFLLYNDQPP QPSKAQDSSM RGHTKGKQLT
     YTYPWVYNYQ LEGIFAQEFP DLENVVKGHH VSQEPWNSSI TLTSQAGAVF QSFAKFSKFG
     DDLYSGWLAA ALGTNLQVQF WHKTVGILPS NCSDIWQV
//