ID   K7ENB4_HUMAN            Unreviewed;       180 AA.
AC   K7ENB4;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   16-JAN-2019, entry version 43.
DE   RecName: Full=Glutathione peroxidase {ECO:0000256|RuleBase:RU000499};
GN   Name=GPX4 {ECO:0000313|Ensembl:ENSP00000466872};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466872, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000466872, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000466872}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000256|RuleBase:RU000499, ECO:0000256|SAAS:SAAS00719801}.
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DR   EMBL; AC004151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7ENB4; -.
DR   EPD; K7ENB4; -.
DR   jPOST; K7ENB4; -.
DR   MaxQB; K7ENB4; -.
DR   PeptideAtlas; K7ENB4; -.
DR   PRIDE; K7ENB4; -.
DR   Ensembl; ENST00000589115; ENSP00000466872; ENSG00000167468.
DR   UCSC; uc060qvo.1; human.
DR   EuPathDB; HostDB:ENSG00000167468.16; -.
DR   HGNC; HGNC:4556; GPX4.
DR   OpenTargets; ENSG00000167468; -.
DR   eggNOG; KOG1651; Eukaryota.
DR   eggNOG; COG0386; LUCA.
DR   GeneTree; ENSGT00940000161913; -.
DR   ChiTaRS; GPX4; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000167468; Expressed in 230 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; K7ENB4; baseline and differential.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029759; GPX_AS.
DR   InterPro; IPR029760; GPX_CS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000499,
KW   ECO:0000256|SAAS:SAAS00719795};
KW   Peroxidase {ECO:0000256|RuleBase:RU000499,
KW   ECO:0000256|SAAS:SAAS00719795};
KW   Proteomics identification {ECO:0000213|EPD:K7ENB4,
KW   ECO:0000213|MaxQB:K7ENB4, ECO:0000213|PeptideAtlas:K7ENB4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    180       Glutathione peroxidase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003903216.
FT   ACT_SITE     73     73       {ECO:0000256|PIRSR:PIRSR000303-1}.
SQ   SEQUENCE   180 AA;  19944 MW;  183FDE38F40EA31B CRC64;
     MSLGRLCRLL KPALLCGALA APGLAGTMCA SRDDWRCARS MHEFSAKDID GHMVNLDKYR
     GFVCIVTNVA SQCGKTEVNY TQLVDLHARY AECGLRILAF PCNQFGKQEP GSNEEIKEFA
     AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNS SSTRTAAWCS ATDPWRSPWC
//