ID   K7EML0_HUMAN            Unreviewed;        79 AA.
AC   K7EML0;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   12-SEP-2018, entry version 37.
DE   SubName: Full=Pancreatic prohormone {ECO:0000313|Ensembl:ENSP00000466546};
GN   Name=PPY {ECO:0000313|Ensembl:ENSP00000466546};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466546, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000466546, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000466546}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NPY family.
CC       {ECO:0000256|RuleBase:RU000656}.
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DR   EMBL; AC007993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EML0; -.
DR   SMR; K7EML0; -.
DR   PeptideAtlas; K7EML0; -.
DR   PRIDE; K7EML0; -.
DR   Ensembl; ENST00000591703; ENSP00000466546; ENSG00000108849.
DR   UCSC; uc060fvo.1; human.
DR   EuPathDB; HostDB:ENSG00000108849.7; -.
DR   HGNC; HGNC:9327; PPY.
DR   OpenTargets; ENSG00000108849; -.
DR   eggNOG; ENOG410J7V9; Eukaryota.
DR   eggNOG; ENOG41115N2; LUCA.
DR   GeneTree; ENSGT00530000064295; -.
DR   ChiTaRS; PPY; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000108849; Expressed in 46 organ(s), highest expression level in type B pancreatic cell.
DR   ExpressionAtlas; K7EML0; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR015480; Pancreatic_hormone.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   PANTHER; PTHR10533:SF2; PTHR10533:SF2; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   ProDom; PD001267; Pancreatic_hormone-like; 1.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19     79       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003904138.
SQ   SEQUENCE   79 AA;  8626 MW;  B8283A744093CE3C CRC64;
     MAAARLCLSL LLLSTCVALL LQPLLGAQGA PLEPVYPGDN ATPEQMAQYA ADLRRYINML
     TRPRPRPMCP GQDGAYRQI
//