ID   K7EMB0_HUMAN            Unreviewed;       255 AA.
AC   K7EMB0;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 28.
DE   SubName: Full=Transmembrane protein 235 {ECO:0000313|Ensembl:ENSP00000466430};
DE   Flags: Fragment;
GN   Name=TMEM235 {ECO:0000313|Ensembl:ENSP00000466430};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466430, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000466430, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000466430}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC087645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EMB0; -.
DR   PeptideAtlas; K7EMB0; -.
DR   Ensembl; ENST00000591033; ENSP00000466430; ENSG00000204278.
DR   UCSC; uc060ktz.1; human.
DR   EuPathDB; HostDB:ENSG00000204278.12; -.
DR   HGNC; HGNC:27563; TMEM235.
DR   OpenTargets; ENSG00000204278; -.
DR   GeneTree; ENSGT00390000011615; -.
DR   OMA; WRICEGQ; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000204278; Expressed in 61 organ(s), highest expression level in substantia nigra.
DR   ExpressionAtlas; K7EMB0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR039951; TMEM114/TMEM235.
DR   PANTHER; PTHR20516; PTHR20516; 2.
DR   Pfam; PF13903; Claudin_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00463381, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:K7EMB0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00463381,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00463381,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    255       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003904131.
FT   TRANSMEM    127    148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    155    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000466430}.
SQ   SEQUENCE   255 AA;  27044 MW;  E694E41910161685 CRC64;
     XLLLAAALGA LLSFALLAAA VASDYWYILE VADAGNGSAW PGRAELLSSH SGLWRICEGQ
     NGCIPLVDPF ASESLDVSTS VQHLICSSQL GWILRALQTP GSPFRTRFFQ MACCLPGWHL
     PPVLHRAVIV VLPLSLVLLV CGWICGLLSS LAQSVSLLLF TGCYFLLGSV LTLAGVSIYI
     SYSHLAFAET VQQYGPQHMQ GVRVSFGWSM ALAWGSCALE AFSGTLLLSA AWTLSLSPPI
     CGHLSPQQVG GRGGD
//