ID   K7EM89_HUMAN            Unreviewed;       149 AA.
AC   K7EM89;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 33.
DE   SubName: Full=Granulins {ECO:0000313|Ensembl:ENSP00000466405};
DE   Flags: Fragment;
GN   Name=GRN {ECO:0000313|Ensembl:ENSP00000466405};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466405, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000466405, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000466405}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC003043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EM89; -.
DR   jPOST; K7EM89; -.
DR   PeptideAtlas; K7EM89; -.
DR   Ensembl; ENST00000593167; ENSP00000466405; ENSG00000030582.
DR   UCSC; uc060fzp.1; human.
DR   EuPathDB; HostDB:ENSG00000030582.16; -.
DR   HGNC; HGNC:4601; GRN.
DR   OpenTargets; ENSG00000030582; -.
DR   eggNOG; KOG4296; Eukaryota.
DR   eggNOG; ENOG410XR6S; LUCA.
DR   GeneTree; ENSGT00470000042293; -.
DR   ChiTaRS; GRN; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000030582; Expressed in 235 organ(s), highest expression level in esophagus mucosa.
DR   ExpressionAtlas; K7EM89; baseline and differential.
DR   Gene3D; 3.10.20.500; -; 1.
DR   InterPro; IPR000118; Granulin.
DR   InterPro; IPR039036; Granulin_fam.
DR   InterPro; IPR037277; Granulin_sf.
DR   PANTHER; PTHR12274; PTHR12274; 1.
DR   Pfam; PF00396; Granulin; 1.
DR   SMART; SM00277; GRAN; 1.
DR   PROSITE; PS00799; GRANULINS; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:K7EM89,
KW   ECO:0000213|PeptideAtlas:K7EM89};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    149       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003903195.
FT   DOMAIN       92    105       GRANULINS. {ECO:0000259|PROSITE:PS00799}.
FT   NON_TER     149    149       {ECO:0000313|Ensembl:ENSP00000466405}.
SQ   SEQUENCE   149 AA;  15581 MW;  B917B6BF1E63B472 CRC64;
     MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP
     CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR SCFQRSGNNS
     VGAIQCPDSQ FECPDFSTCC VMVDGSWGC
//