ID   K7EM43_HUMAN            Unreviewed;       147 AA.
AC   K7EM43;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   RecName: Full=Peptidylprolyl isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
DE            EC=5.2.1.8 {ECO:0000256|PROSITE-ProRule:PRU00277};
GN   Name=FKBP10 {ECO:0000313|Ensembl:ENSP00000466352};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466352, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000466352, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000466352}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000256|PROSITE-
CC         ProRule:PRU00277};
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DR   EMBL; AC091172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EM43; -.
DR   EPD; K7EM43; -.
DR   jPOST; K7EM43; -.
DR   MaxQB; K7EM43; -.
DR   PeptideAtlas; K7EM43; -.
DR   PRIDE; K7EM43; -.
DR   Ensembl; ENST00000489591; ENSP00000466352; ENSG00000141756.
DR   UCSC; uc060fdm.1; human.
DR   EuPathDB; HostDB:ENSG00000141756.18; -.
DR   HGNC; HGNC:18169; FKBP10.
DR   OpenTargets; ENSG00000141756; -.
DR   eggNOG; KOG0549; Eukaryota.
DR   eggNOG; COG0545; LUCA.
DR   GeneTree; ENSGT00940000156331; -.
DR   ChiTaRS; FKBP10; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000141756; Expressed in 137 organ(s), highest expression level in adenohypophysis.
DR   ExpressionAtlas; K7EM43; baseline and differential.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR023566; PPIase_FKBP.
DR   InterPro; IPR001179; PPIase_FKBP_dom.
DR   PANTHER; PTHR10516; PTHR10516; 1.
DR   Pfam; PF00254; FKBP_C; 1.
DR   PROSITE; PS50059; FKBP_PPIASE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
KW   Proteomics identification {ECO:0000213|EPD:K7EM43,
KW   ECO:0000213|MaxQB:K7EM43, ECO:0000213|PeptideAtlas:K7EM43};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Rotamase {ECO:0000256|PROSITE-ProRule:PRU00277};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    147       Peptidylprolyl isomerase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003903192.
FT   DOMAIN       62    126       PPIase FKBP-type.
FT                                {ECO:0000259|PROSITE:PS50059}.
SQ   SEQUENCE   147 AA;  15996 MW;  E3961E5BF1893237 CRC64;
     MFPAGPPSHS LLRLPLLQLL LLVVQAVGRG LGRASPAGGP LEDVVIERYH IPRACPREVQ
     MGDFVRYHYN GTFEDGKKFD SSGAHSTGCH PLLRCGSAGC VEQGRHRAGE HIAAPAPLPP
     HGPGRRLCPL PLQWHPAGRH LLRHQLQ
//