ID   K7ELB9_HUMAN            Unreviewed;       165 AA.
AC   K7ELB9;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 48.
DE   RecName: Full=Fibroblast growth factor {ECO:0000256|RuleBase:RU049442};
DE            Short=FGF {ECO:0000256|RuleBase:RU049442};
GN   Name=FGF22 {ECO:0000313|Ensembl:ENSP00000466004};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466004, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000466004, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000466004}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000256|RuleBase:RU049442, ECO:0000256|SAAS:SAAS00562035}.
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DR   EMBL; AC004449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001287741.1; NM_001300812.1.
DR   UniGene; Hs.248087; -.
DR   ProteinModelPortal; K7ELB9; -.
DR   PRIDE; K7ELB9; -.
DR   Ensembl; ENST00000586042; ENSP00000466004; ENSG00000070388.
DR   GeneID; 27006; -.
DR   UCSC; uc010xfr.2; human.
DR   CTD; 27006; -.
DR   EuPathDB; HostDB:ENSG00000070388.11; -.
DR   HGNC; HGNC:3679; FGF22.
DR   OpenTargets; ENSG00000070388; -.
DR   eggNOG; KOG3885; Eukaryota.
DR   eggNOG; ENOG4111IPH; LUCA.
DR   GeneTree; ENSGT00940000161721; -.
DR   OrthoDB; 1340221at2759; -.
DR   GenomeRNAi; 27006; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000070388; Expressed in 81 organ(s), highest expression level in skin of leg.
DR   ExpressionAtlas; K7ELB9; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028296; FGF22.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF41; PTHR11486:SF41; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Growth factor {ECO:0000256|SAAS:SAAS00065766};
KW   Proteomics identification {ECO:0000213|MaxQB:K7ELB9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU049442}.
FT   SIGNAL        1     22       {ECO:0000256|RuleBase:RU049442}.
FT   CHAIN        23    165       Fibroblast growth factor.
FT                                {ECO:0000256|RuleBase:RU049442}.
FT                                /FTId=PRO_5005138237.
SQ   SEQUENCE   165 AA;  18205 MW;  CF1F21CAF2EC8925 CRC64;
     MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH FFLRVDPGGR
     VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR GRLYGSVPGA HRRERPQHLR
     LTALAPPRPA HVPGAGQEGG APARRPDAAV PPVRPLPARP GLLRP
//