ID   K7EL87_HUMAN            Unreviewed;       140 AA.
AC   K7EL87;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 44.
DE   RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637};
GN   Name=CLDN7 {ECO:0000313|Ensembl:ENSP00000465963};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000465963, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000465963, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000465963}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- FUNCTION: Plays a major role in tight junction-specific
CC       obliteration of the intercellular space, through calcium-
CC       independent cell-adhesion activity.
CC       {ECO:0000256|RuleBase:RU060637}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00567644}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00567644}.
CC   -!- SIMILARITY: Belongs to the claudin family.
CC       {ECO:0000256|RuleBase:RU060637, ECO:0000256|SAAS:SAAS00567656}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC003688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EL87; -.
DR   SMR; K7EL87; -.
DR   jPOST; K7EL87; -.
DR   MaxQB; K7EL87; -.
DR   PeptideAtlas; K7EL87; -.
DR   PRIDE; K7EL87; -.
DR   Ensembl; ENST00000571881; ENSP00000465963; ENSG00000181885.
DR   UCSC; uc060alu.1; human.
DR   EuPathDB; HostDB:ENSG00000181885.18; -.
DR   HGNC; HGNC:2049; CLDN7.
DR   OpenTargets; ENSG00000181885; -.
DR   eggNOG; ENOG410IHPN; Eukaryota.
DR   eggNOG; ENOG4111GPP; LUCA.
DR   GeneTree; ENSGT00940000160672; -.
DR   ChiTaRS; CLDN7; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000181885; Expressed in 143 organ(s), highest expression level in mucosa of transverse colon.
DR   ExpressionAtlas; K7EL87; baseline and differential.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-UniRule.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455883};
KW   Cell membrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455877};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455877, ECO:0000256|SAAS:SAAS00463381};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Tight junction {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455883};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00463381};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00463381}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    140       Claudin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900728.
SQ   SEQUENCE   140 AA;  15112 MW;  A31549B18598949D CRC64;
     MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG
     MMSCKIGLAG HSSPNGGLPG AGLPGHVCGH DGHEVHALWG RRQSEEGPYS HGWRHNFHRG
     RSCRLGSLLL VWPSDCHRLL
//