ID   K7EKW2_HUMAN            Unreviewed;       335 AA.
AC   K7EKW2;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 43.
DE   SubName: Full=Noelin-2 {ECO:0000313|Ensembl:ENSP00000465809};
DE   Flags: Fragment;
GN   Name=OLFM2 {ECO:0000313|Ensembl:ENSP00000465809};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000465809, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000465809, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000465809}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00446}.
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DR   EMBL; AC008742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EKW2; -.
DR   jPOST; K7EKW2; -.
DR   PeptideAtlas; K7EKW2; -.
DR   PRIDE; K7EKW2; -.
DR   Ensembl; ENST00000593091; ENSP00000465809; ENSG00000105088.
DR   UCSC; uc060tda.1; human.
DR   EuPathDB; HostDB:ENSG00000105088.8; -.
DR   HGNC; HGNC:17189; OLFM2.
DR   OpenTargets; ENSG00000105088; -.
DR   eggNOG; ENOG410INP8; Eukaryota.
DR   eggNOG; ENOG410ZRHT; LUCA.
DR   GeneTree; ENSGT00940000159148; -.
DR   ChiTaRS; OLFM2; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000105088; Expressed in 119 organ(s), highest expression level in dorsolateral prefrontal cortex.
DR   ExpressionAtlas; K7EKW2; baseline and differential.
DR   InterPro; IPR031219; Noelin-2.
DR   InterPro; IPR022082; Noelin_dom.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   PANTHER; PTHR23192:SF27; PTHR23192:SF27; 1.
DR   Pfam; PF12308; Noelin-1; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:K7EKW2,
KW   ECO:0000213|PeptideAtlas:K7EKW2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    335       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008419396.
FT   DOMAIN      218    335       Olfactomedin-like.
FT                                {ECO:0000259|PROSITE:PS51132}.
FT   COILED       89    109       {ECO:0000256|SAM:Coils}.
FT   COILED      170    190       {ECO:0000256|SAM:Coils}.
FT   COILED      196    216       {ECO:0000256|SAM:Coils}.
FT   NON_TER     335    335       {ECO:0000313|Ensembl:ENSP00000465809}.
SQ   SEQUENCE   335 AA;  37509 MW;  9332552B5AA9681A CRC64;
     MSVPLLKIGA VLSTMAMVTN WMSQTLPSLV GLNGTVSRAG ASEKITLFQN PEEGWQLYTS
     AQAPDGKCIC TAVIPAQSTC SRDGRSRELR QLMEKVQNVS QSMEVLELRT YRDLQYVRGM
     ETLMRSLDAR LRAADGSLSA KSFQELKDRM TELLPLSSVL EQYKADTRTI VRLREEVRNL
     SGSLAAIQEE MGAYGYEDLQ QRVMALEARL HACAQKLGCG KLTGVSNPIT VRAMGSRFGS
     WMTDTMAPSA DSRVWYMDGY YKGRRVLEFR TLGDFIKGQN FIQHLLPQPW AGTGHVVYNG
     SLFYNKYQSN VVVKYHFRSR SVLVQRSLPG AGYNN
//