ID   K7EJY4_HUMAN            Unreviewed;       163 AA.
AC   K7EJY4;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 34.
DE   SubName: Full=Granulins {ECO:0000313|Ensembl:ENSP00000465375};
DE   Flags: Fragment;
GN   Name=GRN {ECO:0000313|Ensembl:ENSP00000465375};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000465375, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000465375, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000465375}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC003043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EJY4; -.
DR   jPOST; K7EJY4; -.
DR   PeptideAtlas; K7EJY4; -.
DR   PRIDE; K7EJY4; -.
DR   Ensembl; ENST00000588143; ENSP00000465375; ENSG00000030582.
DR   UCSC; uc060fzo.1; human.
DR   EuPathDB; HostDB:ENSG00000030582.16; -.
DR   HGNC; HGNC:4601; GRN.
DR   OpenTargets; ENSG00000030582; -.
DR   eggNOG; KOG4296; Eukaryota.
DR   eggNOG; ENOG410XR6S; LUCA.
DR   GeneTree; ENSGT00470000042293; -.
DR   ChiTaRS; GRN; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000030582; Expressed in 235 organ(s), highest expression level in esophagus mucosa.
DR   ExpressionAtlas; K7EJY4; baseline and differential.
DR   Gene3D; 3.10.20.500; -; 2.
DR   InterPro; IPR000118; Granulin.
DR   InterPro; IPR039036; Granulin_fam.
DR   InterPro; IPR037277; Granulin_sf.
DR   PANTHER; PTHR12274; PTHR12274; 1.
DR   Pfam; PF00396; Granulin; 2.
DR   SMART; SM00277; GRAN; 2.
DR   PROSITE; PS00799; GRANULINS; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:K7EJY4,
KW   ECO:0000213|PeptideAtlas:K7EJY4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    163       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900725.
FT   DOMAIN       92    105       GRANULINS. {ECO:0000259|PROSITE:PS00799}.
FT   NON_TER     163    163       {ECO:0000313|Ensembl:ENSP00000465375}.
SQ   SEQUENCE   163 AA;  17138 MW;  1CCF5ED96357F28A CRC64;
     MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP
     CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR SCFQRSGNNS
     VGAIQCPDSQ FECPDFSTCC VMVDGSWGCC PMPQASCCED RVH
//